Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus
Toll-like receptor (TLR) expression on T-cells and the signalling pathways that lead to the production of cytokines may limit antigen-specific T-cell responses. Here, expression of TLR and retinoic acid inducible gene I (RIG-I) on T-cells were evaluated in patients chronically infected with hepatiti...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/47028 |
| _version_ | 1848757722448658432 |
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| author | Hammond, T. Lee, S. Watson, M. Flexman, J. Cheng, W. Fernandez, S. Price, Patricia |
| author_facet | Hammond, T. Lee, S. Watson, M. Flexman, J. Cheng, W. Fernandez, S. Price, Patricia |
| author_sort | Hammond, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Toll-like receptor (TLR) expression on T-cells and the signalling pathways that lead to the production of cytokines may limit antigen-specific T-cell responses. Here, expression of TLR and retinoic acid inducible gene I (RIG-I) on T-cells were evaluated in patients chronically infected with hepatitis C virus (HCV), before and during pegylated interferon-a and ribavirin therapy. Expression of TLR2,3,4,7,9 and retinoic acid inducible gene (RIG)-I on different CD4+ and CD8+ T-cell sub-populations (naïve: CD45RA+CD57-; central memory: TCM CD45RA-CD57-; effector memory: TEM CD45RA-CD57+ and terminally differentiated effector memory: TEMRA CD45RA+CD57+) were measured by flow cytometry. TLR7, TLR9 and RIG-I expression on CD4+ T-cells and RIG-I expression on CD8+ T-cells was higher in patients than healthy controls. Therapy increased expression of TLR2, TLR4 and TLR9 and this was observed for all T-cell sub-populations. Evaluation of TLR expression at baseline did not identify patients able to achieve sustained virological response following therapy. © 2010. |
| first_indexed | 2025-11-14T09:32:37Z |
| format | Journal Article |
| id | curtin-20.500.11937-47028 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:32:37Z |
| publishDate | 2010 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-470282017-09-13T14:28:07Z Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus Hammond, T. Lee, S. Watson, M. Flexman, J. Cheng, W. Fernandez, S. Price, Patricia Toll-like receptor (TLR) expression on T-cells and the signalling pathways that lead to the production of cytokines may limit antigen-specific T-cell responses. Here, expression of TLR and retinoic acid inducible gene I (RIG-I) on T-cells were evaluated in patients chronically infected with hepatitis C virus (HCV), before and during pegylated interferon-a and ribavirin therapy. Expression of TLR2,3,4,7,9 and retinoic acid inducible gene (RIG)-I on different CD4+ and CD8+ T-cell sub-populations (naïve: CD45RA+CD57-; central memory: TCM CD45RA-CD57-; effector memory: TEM CD45RA-CD57+ and terminally differentiated effector memory: TEMRA CD45RA+CD57+) were measured by flow cytometry. TLR7, TLR9 and RIG-I expression on CD4+ T-cells and RIG-I expression on CD8+ T-cells was higher in patients than healthy controls. Therapy increased expression of TLR2, TLR4 and TLR9 and this was observed for all T-cell sub-populations. Evaluation of TLR expression at baseline did not identify patients able to achieve sustained virological response following therapy. © 2010. 2010 Journal Article http://hdl.handle.net/20.500.11937/47028 10.1016/j.cellimm.2010.06.001 restricted |
| spellingShingle | Hammond, T. Lee, S. Watson, M. Flexman, J. Cheng, W. Fernandez, S. Price, Patricia Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus |
| title | Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus |
| title_full | Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus |
| title_fullStr | Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus |
| title_full_unstemmed | Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus |
| title_short | Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus |
| title_sort | toll-like receptor (tlr) expression on cd4+ and cd8+ t-cells in patients chronically infected with hepatitis c virus |
| url | http://hdl.handle.net/20.500.11937/47028 |