Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis
Background: The teratogenic effects of maternal alcohol consumption during pregnancy include anomalies of craniofacial structures derived from the cranial neural crest cells. The presence of specific craniofacial anomalies contributes to the diagnosis of fetal alcohol spectrum disorders. Cleft lip a...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Wiley-Blackwell Publishing Ltd.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/46858 |
| _version_ | 1848757676633227264 |
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| author | Bell, J. Raynes-Greenow, C. Turner, R. Bower, C. Nassar, N. O'Leary, Colleen Marie |
| author_facet | Bell, J. Raynes-Greenow, C. Turner, R. Bower, C. Nassar, N. O'Leary, Colleen Marie |
| author_sort | Bell, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: The teratogenic effects of maternal alcohol consumption during pregnancy include anomalies of craniofacial structures derived from the cranial neural crest cells. The presence of specific craniofacial anomalies contributes to the diagnosis of fetal alcohol spectrum disorders. Cleft lip and palate [orofacial clefts (OFCs)], also derived from the cranial neural crest cells, are common congenital anomalies, but their relationship with prenatal alcohol consumption is unknown. Methods: To evaluate the association between maternal consumption of alcohol during pregnancy and the occurrence of OFCs in infants, we conducted a systematic review and meta-analyses of published studies. We examined the associations between any alcohol consumption, binge level drinking, and heavy and moderate levels of consumption vs. no or low levels of consumption. Results: After screening 737 publications, we identified 33 studies (23 case–control and 10 cohort studies). There was considerable heterogeneity in individual study design, quality measures and study results. Findings from random effects meta-analyses suggest no relationship between prenatal alcohol consumption and the occurrence of OFCs {pooled odds ratios for any alcohol intake and binge level drinking respectively: cleft lip with or without cleft palate 1.00 [95% confidence interval (CI) 0.86, 1.16] from 18 349 participants in 13 studies, 1.04 [95% CI 0.87,1.24] [8763 individuals, 4 studies]; cleft palate only 1.05 [95% CI 0.92, 1.21] [21 459 individuals, 17 studies], 0.94 [95% CI 0.74, 1.21] [7730 participants, 4 studies]}.Conclusions: While we found no association between alcohol consumption during pregnancy and OFCs in infants, the influence of study design, particularly in relation to alcohol exposure measurement and OFC ascertainment cannot be ignored. |
| first_indexed | 2025-11-14T09:31:53Z |
| format | Journal Article |
| id | curtin-20.500.11937-46858 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:31:53Z |
| publishDate | 2014 |
| publisher | Wiley-Blackwell Publishing Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-468582017-09-13T14:03:55Z Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis Bell, J. Raynes-Greenow, C. Turner, R. Bower, C. Nassar, N. O'Leary, Colleen Marie meta-analysis cleft palate alcohol pregnancy cleft lip Background: The teratogenic effects of maternal alcohol consumption during pregnancy include anomalies of craniofacial structures derived from the cranial neural crest cells. The presence of specific craniofacial anomalies contributes to the diagnosis of fetal alcohol spectrum disorders. Cleft lip and palate [orofacial clefts (OFCs)], also derived from the cranial neural crest cells, are common congenital anomalies, but their relationship with prenatal alcohol consumption is unknown. Methods: To evaluate the association between maternal consumption of alcohol during pregnancy and the occurrence of OFCs in infants, we conducted a systematic review and meta-analyses of published studies. We examined the associations between any alcohol consumption, binge level drinking, and heavy and moderate levels of consumption vs. no or low levels of consumption. Results: After screening 737 publications, we identified 33 studies (23 case–control and 10 cohort studies). There was considerable heterogeneity in individual study design, quality measures and study results. Findings from random effects meta-analyses suggest no relationship between prenatal alcohol consumption and the occurrence of OFCs {pooled odds ratios for any alcohol intake and binge level drinking respectively: cleft lip with or without cleft palate 1.00 [95% confidence interval (CI) 0.86, 1.16] from 18 349 participants in 13 studies, 1.04 [95% CI 0.87,1.24] [8763 individuals, 4 studies]; cleft palate only 1.05 [95% CI 0.92, 1.21] [21 459 individuals, 17 studies], 0.94 [95% CI 0.74, 1.21] [7730 participants, 4 studies]}.Conclusions: While we found no association between alcohol consumption during pregnancy and OFCs in infants, the influence of study design, particularly in relation to alcohol exposure measurement and OFC ascertainment cannot be ignored. 2014 Journal Article http://hdl.handle.net/20.500.11937/46858 10.1111/ppe.12131 Wiley-Blackwell Publishing Ltd. restricted |
| spellingShingle | meta-analysis cleft palate alcohol pregnancy cleft lip Bell, J. Raynes-Greenow, C. Turner, R. Bower, C. Nassar, N. O'Leary, Colleen Marie Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis |
| title | Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis |
| title_full | Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis |
| title_fullStr | Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis |
| title_full_unstemmed | Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis |
| title_short | Maternal Alcohol Consumption during Pregnancy and the Risk of Orofacial Clefts in Infants: a Systematic Review and Meta-Analysis |
| title_sort | maternal alcohol consumption during pregnancy and the risk of orofacial clefts in infants: a systematic review and meta-analysis |
| topic | meta-analysis cleft palate alcohol pregnancy cleft lip |
| url | http://hdl.handle.net/20.500.11937/46858 |