An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles
A catalyst-free highly efficient synthesis of 3(5)-amino-5(3)-(het)aryl-1,2,4-triazoles in aqueous mediumwas performed using conventional heating and microwave irradiation. The tautomerism in the productswas investigated using NMR spectroscopy and X-ray crystallography. The effects of the substituti...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Elsevier Science Limted
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/46409 |
| _version_ | 1848757548961759232 |
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| author | Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. |
| author_facet | Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. |
| author_sort | Dolzhenko, Anton |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A catalyst-free highly efficient synthesis of 3(5)-amino-5(3)-(het)aryl-1,2,4-triazoles in aqueous mediumwas performed using conventional heating and microwave irradiation. The tautomerism in the productswas investigated using NMR spectroscopy and X-ray crystallography. The effects of the substitution, temperature, solvents, and concentration on the tautomerism were studied. The triazoles were found to exist in 1H-forms, the 4H-form was not observed either in solid state or in solution. In general, 5-amino-1,2,4-triazoles were electronically preferred in the tautomeric equilibrium, but some exceptions from theestablished relationship were also identified. |
| first_indexed | 2025-11-14T09:29:51Z |
| format | Journal Article |
| id | curtin-20.500.11937-46409 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:29:51Z |
| publishDate | 2009 |
| publisher | Elsevier Science Limted |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-464092019-02-19T04:26:54Z An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. A catalyst-free highly efficient synthesis of 3(5)-amino-5(3)-(het)aryl-1,2,4-triazoles in aqueous mediumwas performed using conventional heating and microwave irradiation. The tautomerism in the productswas investigated using NMR spectroscopy and X-ray crystallography. The effects of the substitution, temperature, solvents, and concentration on the tautomerism were studied. The triazoles were found to exist in 1H-forms, the 4H-form was not observed either in solid state or in solution. In general, 5-amino-1,2,4-triazoles were electronically preferred in the tautomeric equilibrium, but some exceptions from theestablished relationship were also identified. 2009 Journal Article http://hdl.handle.net/20.500.11937/46409 10.1016/j.tetlet.2009.02.172 Elsevier Science Limted fulltext |
| spellingShingle | Dolzhenko, Anton Pastorin, G. Dolzhenko, A. Chui, W. An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| title | An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| title_full | An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| title_fullStr | An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| title_full_unstemmed | An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| title_short | An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| title_sort | aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles |
| url | http://hdl.handle.net/20.500.11937/46409 |