Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A
Introduction: Botulinum toxin A (BoNTA) is routine treatment for hypertonicity in children with cerebral palsy (CP). Method: Single blind prospective cross sectional study of 10 participants (mean age 11 years,7 months) was done to determine the relationship between muscle histopathology and BoNTA i...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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John Wiley & Sons, Inc
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/46376 |
| _version_ | 1848757540114923520 |
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| author | Valentine, J. Stannage, K. Fabian, V. Ellis, K. Reid, S. Pitcher, C. Elliott, Catherine |
| author_facet | Valentine, J. Stannage, K. Fabian, V. Ellis, K. Reid, S. Pitcher, C. Elliott, Catherine |
| author_sort | Valentine, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Introduction: Botulinum toxin A (BoNTA) is routine treatment for hypertonicity in children with cerebral palsy (CP). Method: Single blind prospective cross sectional study of 10 participants (mean age 11 years,7 months) was done to determine the relationship between muscle histopathology and BoNTA in treated medial gastrocnemius muscle of children with CP. Open muscle biopsies were taken from medial gastrocnemius muscle and vastus lateralis (control) during orthopedic surgery. Results: Neurogenic atrophy in the medial gastrocnemius was seen in 6 participants between 4 months to 3 years post BoNTA. Type 1 fiber loss with type 2 fiber predominance was significantly related to the number of BoNTA injections (r = 0.89, P < 0.001). Discussion: The impact of these changes in muscle morphology on muscle function in CP is not clear. It is important to consider rotating muscle selection or injection sites within the muscle or allowing longer time between injections. |
| first_indexed | 2025-11-14T09:29:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-46376 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:29:43Z |
| publishDate | 2015 |
| publisher | John Wiley & Sons, Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-463762017-09-13T13:37:32Z Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A Valentine, J. Stannage, K. Fabian, V. Ellis, K. Reid, S. Pitcher, C. Elliott, Catherine botulinum toxin medial gastrocnemius hypertonia Cerebral Palsy muscle histopathology neurogenic atrophy Introduction: Botulinum toxin A (BoNTA) is routine treatment for hypertonicity in children with cerebral palsy (CP). Method: Single blind prospective cross sectional study of 10 participants (mean age 11 years,7 months) was done to determine the relationship between muscle histopathology and BoNTA in treated medial gastrocnemius muscle of children with CP. Open muscle biopsies were taken from medial gastrocnemius muscle and vastus lateralis (control) during orthopedic surgery. Results: Neurogenic atrophy in the medial gastrocnemius was seen in 6 participants between 4 months to 3 years post BoNTA. Type 1 fiber loss with type 2 fiber predominance was significantly related to the number of BoNTA injections (r = 0.89, P < 0.001). Discussion: The impact of these changes in muscle morphology on muscle function in CP is not clear. It is important to consider rotating muscle selection or injection sites within the muscle or allowing longer time between injections. 2015 Journal Article http://hdl.handle.net/20.500.11937/46376 10.1002/mus.24763 John Wiley & Sons, Inc restricted |
| spellingShingle | botulinum toxin medial gastrocnemius hypertonia Cerebral Palsy muscle histopathology neurogenic atrophy Valentine, J. Stannage, K. Fabian, V. Ellis, K. Reid, S. Pitcher, C. Elliott, Catherine Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A |
| title | Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A |
| title_full | Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A |
| title_fullStr | Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A |
| title_full_unstemmed | Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A |
| title_short | Muscle Histopathology in Children with Spastic Cerebral Palsy Receiving Botulinum toxin Type A |
| title_sort | muscle histopathology in children with spastic cerebral palsy receiving botulinum toxin type a |
| topic | botulinum toxin medial gastrocnemius hypertonia Cerebral Palsy muscle histopathology neurogenic atrophy |
| url | http://hdl.handle.net/20.500.11937/46376 |