4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
The trichloromethyl moiety was successfully employed as a leaving group in nucleophilic substitutions with various amines for the synthesis of 4-amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines. The key precursor for this reaction, 4-trichloromethylpyrazolo[1,5-a][1,3,5]triazin-2-amine, was...
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| Format: | Journal Article |
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Pergamon
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/46256 |
| _version_ | 1848757508656594944 |
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| author | Lim, Felicia Phei Lin Dolzhenko, Anton |
| author_facet | Lim, Felicia Phei Lin Dolzhenko, Anton |
| author_sort | Lim, Felicia Phei Lin |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The trichloromethyl moiety was successfully employed as a leaving group in nucleophilic substitutions with various amines for the synthesis of 4-amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines. The key precursor for this reaction, 4-trichloromethylpyrazolo[1,5-a][1,3,5]triazin-2-amine, was prepared via the solvent-dependent condensation of 5-guanidino-3-phenylpyrazole with trichloroacetonitrile. In a broad biological activity screening, some of the prepared compounds were identified as CGRP receptor antagonists. |
| first_indexed | 2025-11-14T09:29:13Z |
| format | Journal Article |
| id | curtin-20.500.11937-46256 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:29:13Z |
| publishDate | 2014 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-462562017-09-13T15:05:24Z 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity Lim, Felicia Phei Lin Dolzhenko, Anton Trichloroacetonitrile Aminolysis Triazine Pyrazole Purine analogue The trichloromethyl moiety was successfully employed as a leaving group in nucleophilic substitutions with various amines for the synthesis of 4-amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines. The key precursor for this reaction, 4-trichloromethylpyrazolo[1,5-a][1,3,5]triazin-2-amine, was prepared via the solvent-dependent condensation of 5-guanidino-3-phenylpyrazole with trichloroacetonitrile. In a broad biological activity screening, some of the prepared compounds were identified as CGRP receptor antagonists. 2014 Journal Article http://hdl.handle.net/20.500.11937/46256 10.1016/j.tetlet.2014.10.057 Pergamon restricted |
| spellingShingle | Trichloroacetonitrile Aminolysis Triazine Pyrazole Purine analogue Lim, Felicia Phei Lin Dolzhenko, Anton 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| title | 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| title_full | 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| title_fullStr | 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| title_full_unstemmed | 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| title_short | 4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| title_sort | 4-amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity |
| topic | Trichloroacetonitrile Aminolysis Triazine Pyrazole Purine analogue |
| url | http://hdl.handle.net/20.500.11937/46256 |