Analysis of the intricate relationship between chronic inflammation and cancer
Deregulated inflammatory response plays a pivotal role in the initiation, development and progression of tumours. Potential molecular mechanism(s) that drive the establishment of an inflammatory-tumour microenvironment is not entirely understood owing to the complex cross-talk between proinflammator...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Portland Press Ltd
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/46172 |
| _version_ | 1848757485272301568 |
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| author | Chai, E. Siveen, K. Shanmugam, M. Arfuso, Frank Sethi, G. |
| author_facet | Chai, E. Siveen, K. Shanmugam, M. Arfuso, Frank Sethi, G. |
| author_sort | Chai, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Deregulated inflammatory response plays a pivotal role in the initiation, development and progression of tumours. Potential molecular mechanism(s) that drive the establishment of an inflammatory-tumour microenvironment is not entirely understood owing to the complex cross-talk between proinflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer, and their activation and/or deactivation are influenced by both extrinsic (i.e. environmental and lifestyle) and intrinsic (i.e. hereditary) factors. At present, the research pertaining to inflammation-associated cancers is accumulating at an exponential rate. Interest stems from hope that new therapeutic strategies against molecular mediators can be identified to assist in cancer treatment and patient management. The present review outlines the various molecular and cellular inflammatory mediators responsible for tumour initiation, progression and development, and discusses the critical role of chronic inflammation in tumorigenesis. |
| first_indexed | 2025-11-14T09:28:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-46172 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:28:50Z |
| publishDate | 2015 |
| publisher | Portland Press Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-461722017-09-13T15:15:32Z Analysis of the intricate relationship between chronic inflammation and cancer Chai, E. Siveen, K. Shanmugam, M. Arfuso, Frank Sethi, G. Deregulated inflammatory response plays a pivotal role in the initiation, development and progression of tumours. Potential molecular mechanism(s) that drive the establishment of an inflammatory-tumour microenvironment is not entirely understood owing to the complex cross-talk between proinflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer, and their activation and/or deactivation are influenced by both extrinsic (i.e. environmental and lifestyle) and intrinsic (i.e. hereditary) factors. At present, the research pertaining to inflammation-associated cancers is accumulating at an exponential rate. Interest stems from hope that new therapeutic strategies against molecular mediators can be identified to assist in cancer treatment and patient management. The present review outlines the various molecular and cellular inflammatory mediators responsible for tumour initiation, progression and development, and discusses the critical role of chronic inflammation in tumorigenesis. 2015 Journal Article http://hdl.handle.net/20.500.11937/46172 10.1042/BJ20141337 Portland Press Ltd restricted |
| spellingShingle | Chai, E. Siveen, K. Shanmugam, M. Arfuso, Frank Sethi, G. Analysis of the intricate relationship between chronic inflammation and cancer |
| title | Analysis of the intricate relationship between chronic inflammation and cancer |
| title_full | Analysis of the intricate relationship between chronic inflammation and cancer |
| title_fullStr | Analysis of the intricate relationship between chronic inflammation and cancer |
| title_full_unstemmed | Analysis of the intricate relationship between chronic inflammation and cancer |
| title_short | Analysis of the intricate relationship between chronic inflammation and cancer |
| title_sort | analysis of the intricate relationship between chronic inflammation and cancer |
| url | http://hdl.handle.net/20.500.11937/46172 |