Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease
The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/45949 |
| _version_ | 1848757426110595072 |
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| author | Affandi, J. Hendry, S. Waterer, G. Thomson, R. Wallace, H. Burrows, S. Price, Patricia |
| author_facet | Affandi, J. Hendry, S. Waterer, G. Thomson, R. Wallace, H. Burrows, S. Price, Patricia |
| author_sort | Affandi, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms (SNP) affecting cytokines, chemokines and their receptors associate with pulmonary NTM disease. Samples from NTM patients (n=79) and healthy controls (n=188) were genotyped using TaqMan probes. Of the 16 SNPs assessed, IL28B-rs8099917*TG (rs8099917; P=0.01, OR=2.2), TNFA-1031*CC (rs1799964; p=0.02, OR=0.48) and IL10-1082*AA (rs1800896; P=0.001, OR=0.33) were significantly associated with NTM disease. IL28B-rs8099917 and IL10-1082 have been associated with perturbations of the Th1/Th2 balance, whilst TNFA-1031*CC associates with sensory neuropathy in HIV patients. IL10-1082 warrants further investigation because we observed high production of IL-10 in blood mononuclear cells from NTM patients. © 2013 American Society for Histocompatibility and Immunogenetics. |
| first_indexed | 2025-11-14T09:27:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-45949 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:27:54Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-459492017-09-13T14:24:47Z Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease Affandi, J. Hendry, S. Waterer, G. Thomson, R. Wallace, H. Burrows, S. Price, Patricia The incidence of pulmonary non-tuberculous mycobacteria (NTM) disease in otherwise healthy adults is increasing as the population ages. The organisms are ubiquitous so susceptibility probably reflects a deficiency in a protective immune response. Here we investigate if singlenucleotide polymorphisms (SNP) affecting cytokines, chemokines and their receptors associate with pulmonary NTM disease. Samples from NTM patients (n=79) and healthy controls (n=188) were genotyped using TaqMan probes. Of the 16 SNPs assessed, IL28B-rs8099917*TG (rs8099917; P=0.01, OR=2.2), TNFA-1031*CC (rs1799964; p=0.02, OR=0.48) and IL10-1082*AA (rs1800896; P=0.001, OR=0.33) were significantly associated with NTM disease. IL28B-rs8099917 and IL10-1082 have been associated with perturbations of the Th1/Th2 balance, whilst TNFA-1031*CC associates with sensory neuropathy in HIV patients. IL10-1082 warrants further investigation because we observed high production of IL-10 in blood mononuclear cells from NTM patients. © 2013 American Society for Histocompatibility and Immunogenetics. 2013 Journal Article http://hdl.handle.net/20.500.11937/45949 10.1016/j.humimm.2013.06.019 restricted |
| spellingShingle | Affandi, J. Hendry, S. Waterer, G. Thomson, R. Wallace, H. Burrows, S. Price, Patricia Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| title | Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| title_full | Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| title_fullStr | Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| title_full_unstemmed | Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| title_short | Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| title_sort | searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease |
| url | http://hdl.handle.net/20.500.11937/45949 |