The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy
Some HIV patients who previously experienced severe immunodeficiency retain low pathogen-specific T-cell responses despite a virological response to antiretroviral therapy (ART). To identify correlates with dysfunction in accessory cell populations, HIV patients were stratified into groups maintaini...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Academic Press
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/45936 |
| _version_ | 1848757422404927488 |
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| author | Fernandez, S. Stone, S. Price, Patricia French, M. |
| author_facet | Fernandez, S. Stone, S. Price, Patricia French, M. |
| author_sort | Fernandez, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Some HIV patients who previously experienced severe immunodeficiency retain low pathogen-specific T-cell responses despite a virological response to antiretroviral therapy (ART). To identify correlates with dysfunction in accessory cell populations, HIV patients were stratified into groups maintaining high or low CD4+ T-cell IFN-? responses to cytomegalovirus (CMV) over 4-8 years on ART. Myeloid dendritic cells (mDC), plasmacytoid (p) DC, M-DC8+ cells and monocytes were enumerated and mRNA of cytokines and activation molecules were quantitated in purified subpopulations. Proportions of pDC were lower (p = 0.043) and mDC were higher (p = 0.043) in low responders. TRAIL receptor 2 (DR5) mRNA levels in pDC (p = 0.0008) and mDC (p = 0.0062) were lower in high responders compared to controls. Levels of IL-15 mRNA were higher in mDC from high responders (p = 0.015) and levels of IL-10 mRNA were higher in M-DC8+ cells from low responders (p = 0.036). Hence CMV-specific CD4+ T-cell IFN-? responses may be affected by numbers and function of circulating DC. © 2008 Elsevier Inc. All rights reserved. |
| first_indexed | 2025-11-14T09:27:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-45936 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:27:50Z |
| publishDate | 2008 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-459362017-09-13T14:26:50Z The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy Fernandez, S. Stone, S. Price, Patricia French, M. Some HIV patients who previously experienced severe immunodeficiency retain low pathogen-specific T-cell responses despite a virological response to antiretroviral therapy (ART). To identify correlates with dysfunction in accessory cell populations, HIV patients were stratified into groups maintaining high or low CD4+ T-cell IFN-? responses to cytomegalovirus (CMV) over 4-8 years on ART. Myeloid dendritic cells (mDC), plasmacytoid (p) DC, M-DC8+ cells and monocytes were enumerated and mRNA of cytokines and activation molecules were quantitated in purified subpopulations. Proportions of pDC were lower (p = 0.043) and mDC were higher (p = 0.043) in low responders. TRAIL receptor 2 (DR5) mRNA levels in pDC (p = 0.0008) and mDC (p = 0.0062) were lower in high responders compared to controls. Levels of IL-15 mRNA were higher in mDC from high responders (p = 0.015) and levels of IL-10 mRNA were higher in M-DC8+ cells from low responders (p = 0.036). Hence CMV-specific CD4+ T-cell IFN-? responses may be affected by numbers and function of circulating DC. © 2008 Elsevier Inc. All rights reserved. 2008 Journal Article http://hdl.handle.net/20.500.11937/45936 10.1016/j.clim.2008.03.517 Academic Press restricted |
| spellingShingle | Fernandez, S. Stone, S. Price, Patricia French, M. The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy |
| title | The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy |
| title_full | The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy |
| title_fullStr | The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy |
| title_full_unstemmed | The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy |
| title_short | The number and function of circulating dendritic cells may limit effector memory CD4+ T-cell responses in HIV patients responding to antiretroviral therapy |
| title_sort | number and function of circulating dendritic cells may limit effector memory cd4+ t-cell responses in hiv patients responding to antiretroviral therapy |
| url | http://hdl.handle.net/20.500.11937/45936 |