The profile of psychiatric symptoms exacerbated by methamphetamine use
Background: Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to e...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Elsevier Ireland Ltd
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/45917 |
| _version_ | 1848757417211330560 |
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| author | McKetin, Rebecca Dawe, S. Burns, R. Hides, L. Kavanagh, D. Teesson, M. McD Young, R. |
| author_facet | McKetin, Rebecca Dawe, S. Burns, R. Hides, L. Kavanagh, D. Teesson, M. McD Young, R. |
| author_sort | McKetin, Rebecca |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use. Methods: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale. Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis. Results: Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ2(df1) = 3.66, p = 0.056). Conclusion: Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome. |
| first_indexed | 2025-11-14T09:27:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-45917 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:27:46Z |
| publishDate | 2016 |
| publisher | Elsevier Ireland Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-459172017-09-13T14:24:11Z The profile of psychiatric symptoms exacerbated by methamphetamine use McKetin, Rebecca Dawe, S. Burns, R. Hides, L. Kavanagh, D. Teesson, M. McD Young, R. Background: Methamphetamine use can produce symptoms almost indistinguishable from schizophrenia. Distinguishing between the two conditions has been hampered by the lack of a validated symptom profile for methamphetamine-induced psychiatric symptoms. We use data from a longitudinal cohort study to examine the profile of psychiatric symptoms that are acutely exacerbated by methamphetamine use. Methods: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale. Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis. Results: Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ2(df1) = 3.66, p = 0.056). Conclusion: Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome. 2016 Journal Article http://hdl.handle.net/20.500.11937/45917 10.1016/j.drugalcdep.2016.01.018 Elsevier Ireland Ltd fulltext |
| spellingShingle | McKetin, Rebecca Dawe, S. Burns, R. Hides, L. Kavanagh, D. Teesson, M. McD Young, R. The profile of psychiatric symptoms exacerbated by methamphetamine use |
| title | The profile of psychiatric symptoms exacerbated by methamphetamine use |
| title_full | The profile of psychiatric symptoms exacerbated by methamphetamine use |
| title_fullStr | The profile of psychiatric symptoms exacerbated by methamphetamine use |
| title_full_unstemmed | The profile of psychiatric symptoms exacerbated by methamphetamine use |
| title_short | The profile of psychiatric symptoms exacerbated by methamphetamine use |
| title_sort | profile of psychiatric symptoms exacerbated by methamphetamine use |
| url | http://hdl.handle.net/20.500.11937/45917 |