Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1
Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2012
|
| Online Access: | http://hdl.handle.net/20.500.11937/45881 |
| _version_ | 1848757407640977408 |
|---|---|
| author | Aghafar, M. Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M. Rodriguez, B. Senitzer, D. Lee, S. Price, Patricia |
| author_facet | Aghafar, M. Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M. Rodriguez, B. Senitzer, D. Lee, S. Price, Patricia |
| author_sort | Aghafar, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort. |
| first_indexed | 2025-11-14T09:27:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-45881 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:27:36Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-458812017-09-13T14:26:49Z Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 Aghafar, M. Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M. Rodriguez, B. Senitzer, D. Lee, S. Price, Patricia Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort. 2012 Journal Article http://hdl.handle.net/20.500.11937/45881 10.1111/j.1399-0039.2012.01843.x restricted |
| spellingShingle | Aghafar, M. Witt, C. Kamarulzaman, A. Ismail, R. Lederman, M. Rodriguez, B. Senitzer, D. Lee, S. Price, Patricia Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 |
| title | Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 |
| title_full | Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 |
| title_fullStr | Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 |
| title_full_unstemmed | Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 |
| title_short | Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1 |
| title_sort | genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to hiv-1 |
| url | http://hdl.handle.net/20.500.11937/45881 |