Convergent transcriptional specializations in the brains of humans and song-learning birds
Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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The American Association for the Advancement of Science
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/45716 |
| _version_ | 1848757362428477440 |
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| author | Pfenning, A. Hara, E. Whitney, O. Rivas, M. Wang, R. Roulhac, P. Howard, J. Wirthlin, M. Lovell, P. Ganapathy, G. Mouncastle, J. Moseley, M.A. Thompson, J W. Soderblom, E.j Iriki, A. Kato, M. Gilbert, Thomas Zhang, G. Bakken, T. Bongaarts, A. Bernard, A. Lein, E. Mello, C. Hartemink, A. Jarvis, E. |
| author_facet | Pfenning, A. Hara, E. Whitney, O. Rivas, M. Wang, R. Roulhac, P. Howard, J. Wirthlin, M. Lovell, P. Ganapathy, G. Mouncastle, J. Moseley, M.A. Thompson, J W. Soderblom, E.j Iriki, A. Kato, M. Gilbert, Thomas Zhang, G. Bakken, T. Bongaarts, A. Bernard, A. Lein, E. Mello, C. Hartemink, A. Jarvis, E. |
| author_sort | Pfenning, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes. |
| first_indexed | 2025-11-14T09:26:53Z |
| format | Journal Article |
| id | curtin-20.500.11937-45716 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:26:53Z |
| publishDate | 2014 |
| publisher | The American Association for the Advancement of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-457162023-02-22T06:24:23Z Convergent transcriptional specializations in the brains of humans and song-learning birds Pfenning, A. Hara, E. Whitney, O. Rivas, M. Wang, R. Roulhac, P. Howard, J. Wirthlin, M. Lovell, P. Ganapathy, G. Mouncastle, J. Moseley, M.A. Thompson, J W. Soderblom, E.j Iriki, A. Kato, M. Gilbert, Thomas Zhang, G. Bakken, T. Bongaarts, A. Bernard, A. Lein, E. Mello, C. Hartemink, A. Jarvis, E. Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes. 2014 Journal Article http://hdl.handle.net/20.500.11937/45716 10.1126/science.1256846 The American Association for the Advancement of Science unknown |
| spellingShingle | Pfenning, A. Hara, E. Whitney, O. Rivas, M. Wang, R. Roulhac, P. Howard, J. Wirthlin, M. Lovell, P. Ganapathy, G. Mouncastle, J. Moseley, M.A. Thompson, J W. Soderblom, E.j Iriki, A. Kato, M. Gilbert, Thomas Zhang, G. Bakken, T. Bongaarts, A. Bernard, A. Lein, E. Mello, C. Hartemink, A. Jarvis, E. Convergent transcriptional specializations in the brains of humans and song-learning birds |
| title | Convergent transcriptional specializations in the brains of humans and song-learning birds |
| title_full | Convergent transcriptional specializations in the brains of humans and song-learning birds |
| title_fullStr | Convergent transcriptional specializations in the brains of humans and song-learning birds |
| title_full_unstemmed | Convergent transcriptional specializations in the brains of humans and song-learning birds |
| title_short | Convergent transcriptional specializations in the brains of humans and song-learning birds |
| title_sort | convergent transcriptional specializations in the brains of humans and song-learning birds |
| url | http://hdl.handle.net/20.500.11937/45716 |