Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART
Some HIV/hepatitis C virus co-infected patients beginning ART experience Immune Restoration Disease (IRD) manifested as a rise in serum alanine transaminase. This was investigated in HIV/HCV co-infected individuals (n = 50) commencing ART in Jakarta (Indonesia). Samples were collected at weeks 0, 4,...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Academic Press Inc.
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/45675 |
| _version_ | 1848757350953910272 |
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| author | Yunihastuti, E. Lee, S. Gani, R. Saraswati, H. Sundaru, H. Lesmana, L. Sukmana, N. Price, Patricia |
| author_facet | Yunihastuti, E. Lee, S. Gani, R. Saraswati, H. Sundaru, H. Lesmana, L. Sukmana, N. Price, Patricia |
| author_sort | Yunihastuti, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Some HIV/hepatitis C virus co-infected patients beginning ART experience Immune Restoration Disease (IRD) manifested as a rise in serum alanine transaminase. This was investigated in HIV/HCV co-infected individuals (n = 50) commencing ART in Jakarta (Indonesia). Samples were collected at weeks 0, 4, 8, 12, 24 and at HCV IRD. Nine patients experienced HCV IRD (incidence = 9.2 per 1000 person-weeks). These resolved without changing treatment. Markers of T-cell activation (sCD26, sCD30) and immune recruitment (CXCL10) increased in many HCV IRD cases, so T-cells may mediate HCV IRD. Total anti-HCV antibody (core, NS3, NS4) remained lower in HCV IRD cases, but levels of antibody to core were not lower in HCV IRD cases. Rises in HCV RNA on ART were independent of HCV IRD, but there was a negative correlation between baseline HCV RNA and total anti-HCV antibody. High levels of antibody may protect against HCV IRD, via lower HCV antigen loads. © 2011 Elsevier Inc. |
| first_indexed | 2025-11-14T09:26:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-45675 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:26:42Z |
| publishDate | 2011 |
| publisher | Academic Press Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-456752017-09-13T14:24:48Z Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART Yunihastuti, E. Lee, S. Gani, R. Saraswati, H. Sundaru, H. Lesmana, L. Sukmana, N. Price, Patricia Some HIV/hepatitis C virus co-infected patients beginning ART experience Immune Restoration Disease (IRD) manifested as a rise in serum alanine transaminase. This was investigated in HIV/HCV co-infected individuals (n = 50) commencing ART in Jakarta (Indonesia). Samples were collected at weeks 0, 4, 8, 12, 24 and at HCV IRD. Nine patients experienced HCV IRD (incidence = 9.2 per 1000 person-weeks). These resolved without changing treatment. Markers of T-cell activation (sCD26, sCD30) and immune recruitment (CXCL10) increased in many HCV IRD cases, so T-cells may mediate HCV IRD. Total anti-HCV antibody (core, NS3, NS4) remained lower in HCV IRD cases, but levels of antibody to core were not lower in HCV IRD cases. Rises in HCV RNA on ART were independent of HCV IRD, but there was a negative correlation between baseline HCV RNA and total anti-HCV antibody. High levels of antibody may protect against HCV IRD, via lower HCV antigen loads. © 2011 Elsevier Inc. 2011 Journal Article http://hdl.handle.net/20.500.11937/45675 10.1016/j.clim.2010.12.013 Academic Press Inc. restricted |
| spellingShingle | Yunihastuti, E. Lee, S. Gani, R. Saraswati, H. Sundaru, H. Lesmana, L. Sukmana, N. Price, Patricia Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART |
| title | Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART |
| title_full | Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART |
| title_fullStr | Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART |
| title_full_unstemmed | Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART |
| title_short | Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART |
| title_sort | antibody and markers of t-cell activation illuminate the pathogenesis of hcv immune restoration disease in hiv/hcv co-infected patients commencing art |
| url | http://hdl.handle.net/20.500.11937/45675 |