Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor
Host survival depends on an effective immune system and pathogen survival on the effectiveness of immune evasion mechanisms. Staphylococcus aureus utilizes a number of molecules to modulate host immunity, including the SSL family of which SSL7 binds IgA and inhibits Fca receptor I (FcaRI)-mediated f...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/45571 |
| _version_ | 1848757322704224256 |
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| author | Wines, B. Ramsland, Paul Trist, H. Gardam, S. Brink, R. Fraser, J. Hogarth, P. |
| author_facet | Wines, B. Ramsland, Paul Trist, H. Gardam, S. Brink, R. Fraser, J. Hogarth, P. |
| author_sort | Wines, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Host survival depends on an effective immune system and pathogen survival on the effectiveness of immune evasion mechanisms. Staphylococcus aureus utilizes a number of molecules to modulate host immunity, including the SSL family of which SSL7 binds IgA and inhibits Fca receptor I (FcaRI)-mediated function. Other Gram-positive bacterial pathogens produce IgA binding proteins, which, similar to SSL7, also bind the Fc at the CH2/CH3 interface (the junction between constant domains 2 and 3 of the heavy chain). The opposing activities of the host FcaRI-IgA receptor ligand pair and the pathogen decoy proteins select for host and pathogen variants, which exert stronger protection or evasion, respectively. Curiously, mouse but not rat IgA contains a putative N-linked glycosylation site in the center of this host receptor and pathogen-binding site. Here, we demonstrate that this site is glycosylated and that the effect of amino acid changes and glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. |
| first_indexed | 2025-11-14T09:26:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-45571 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:26:15Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-455712017-09-13T14:23:35Z Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor Wines, B. Ramsland, Paul Trist, H. Gardam, S. Brink, R. Fraser, J. Hogarth, P. Host survival depends on an effective immune system and pathogen survival on the effectiveness of immune evasion mechanisms. Staphylococcus aureus utilizes a number of molecules to modulate host immunity, including the SSL family of which SSL7 binds IgA and inhibits Fca receptor I (FcaRI)-mediated function. Other Gram-positive bacterial pathogens produce IgA binding proteins, which, similar to SSL7, also bind the Fc at the CH2/CH3 interface (the junction between constant domains 2 and 3 of the heavy chain). The opposing activities of the host FcaRI-IgA receptor ligand pair and the pathogen decoy proteins select for host and pathogen variants, which exert stronger protection or evasion, respectively. Curiously, mouse but not rat IgA contains a putative N-linked glycosylation site in the center of this host receptor and pathogen-binding site. Here, we demonstrate that this site is glycosylated and that the effect of amino acid changes and glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc. 2011 Journal Article http://hdl.handle.net/20.500.11937/45571 10.1074/jbc.M111.272252 unknown |
| spellingShingle | Wines, B. Ramsland, Paul Trist, H. Gardam, S. Brink, R. Fraser, J. Hogarth, P. Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor |
| title | Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor |
| title_full | Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor |
| title_fullStr | Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor |
| title_full_unstemmed | Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor |
| title_short | Interaction of human, rat, and mouse immunoglobulin A (IgA) with staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor |
| title_sort | interaction of human, rat, and mouse immunoglobulin a (iga) with staphylococcal superantigen-like 7 (ssl7) decoy protein and leukocyte iga receptor |
| url | http://hdl.handle.net/20.500.11937/45571 |