A Small Molecule Inhibitor of PDK1/PLCy1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion.

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A Small Molecule Inhibitor of PDK1/PLCy1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion.

Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a protein complex with 3-phosphoinositidedependent prote...

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Bibliographic Details
Main Authors:	Raimondi, C., Calleja, V., Ferro, R., Fantin, A., Riley, A., Potter, B., Brennan, C., Maffucci, T., Larijani, B., Falasca, Marco
Format:	Journal Article
Published:	Nature Publishing Group 2016
Online Access:	http://hdl.handle.net/20.500.11937/45537

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