Role of Wnt signalling in early pregnancy
The integration of a complex network of signalling molecules promotes implantation of the blastocyst and development of the placenta. These processes are crucial for a successful pregnancy and fetal growth and development. The signalling network involves both cell–cell and cell–extracellular matrix...
| Main Authors: | , , , |
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| Format: | Journal Article |
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C S I R O Publishing
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/45476 |
| _version_ | 1848757295312273408 |
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| author | Nayeem, S. Arfuso, Frank Dharmarajan, Arunasalam Keelan, J. |
| author_facet | Nayeem, S. Arfuso, Frank Dharmarajan, Arunasalam Keelan, J. |
| author_sort | Nayeem, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The integration of a complex network of signalling molecules promotes implantation of the blastocyst and development of the placenta. These processes are crucial for a successful pregnancy and fetal growth and development. The signalling network involves both cell–cell and cell–extracellular matrix communication. The family of secreted glycoprotein ligands, the Wnts, plays a major role in regulating a wide range of biological processes, including embryonic development, cell fate, proliferation, migration, stem cell maintenance, tumour suppression, oncogenesis and tissue homeostasis. Recent studies have provided evidence that Wnt signalling pathways play an important role in reproductive tissues and in early pregnancy events. The focus of this review is to summarise our present knowledge of expression, regulation and function of the Wnt signalling pathways in early pregnancy events of human and other model systems, and its association with pathological conditions. Despite our recent progress, much remains to be learned about Wnt signalling in human reproduction. The advancement of knowledge in this area has applications in the reduction of infertility and the incidence and morbidity of gestational diseases. |
| first_indexed | 2025-11-14T09:25:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-45476 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:25:49Z |
| publishDate | 2015 |
| publisher | C S I R O Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-454762017-09-13T14:20:16Z Role of Wnt signalling in early pregnancy Nayeem, S. Arfuso, Frank Dharmarajan, Arunasalam Keelan, J. decidua trophoblast endometrium placenta The integration of a complex network of signalling molecules promotes implantation of the blastocyst and development of the placenta. These processes are crucial for a successful pregnancy and fetal growth and development. The signalling network involves both cell–cell and cell–extracellular matrix communication. The family of secreted glycoprotein ligands, the Wnts, plays a major role in regulating a wide range of biological processes, including embryonic development, cell fate, proliferation, migration, stem cell maintenance, tumour suppression, oncogenesis and tissue homeostasis. Recent studies have provided evidence that Wnt signalling pathways play an important role in reproductive tissues and in early pregnancy events. The focus of this review is to summarise our present knowledge of expression, regulation and function of the Wnt signalling pathways in early pregnancy events of human and other model systems, and its association with pathological conditions. Despite our recent progress, much remains to be learned about Wnt signalling in human reproduction. The advancement of knowledge in this area has applications in the reduction of infertility and the incidence and morbidity of gestational diseases. 2015 Journal Article http://hdl.handle.net/20.500.11937/45476 10.1071/RD14079 C S I R O Publishing restricted |
| spellingShingle | decidua trophoblast endometrium placenta Nayeem, S. Arfuso, Frank Dharmarajan, Arunasalam Keelan, J. Role of Wnt signalling in early pregnancy |
| title | Role of Wnt signalling in early pregnancy |
| title_full | Role of Wnt signalling in early pregnancy |
| title_fullStr | Role of Wnt signalling in early pregnancy |
| title_full_unstemmed | Role of Wnt signalling in early pregnancy |
| title_short | Role of Wnt signalling in early pregnancy |
| title_sort | role of wnt signalling in early pregnancy |
| topic | decidua trophoblast endometrium placenta |
| url | http://hdl.handle.net/20.500.11937/45476 |