Synthesis and characterization of novel copolymeric resveratrol conjugates
Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/45196 |
| _version_ | 1848757215790366720 |
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| author | Ng, Y. Benson, Heather Brown, D. Chen, Y. |
| author_facet | Ng, Y. Benson, Heather Brown, D. Chen, Y. |
| author_sort | Ng, Y. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(e-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminary in vitro stability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma. |
| first_indexed | 2025-11-14T09:24:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-45196 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:24:33Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-451962017-09-13T14:22:51Z Synthesis and characterization of novel copolymeric resveratrol conjugates Ng, Y. Benson, Heather Brown, D. Chen, Y. Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(e-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminary in vitro stability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma. 2015 Journal Article http://hdl.handle.net/20.500.11937/45196 10.1155/2015/245625 Hindawi Publishing Corporation fulltext |
| spellingShingle | Ng, Y. Benson, Heather Brown, D. Chen, Y. Synthesis and characterization of novel copolymeric resveratrol conjugates |
| title | Synthesis and characterization of novel copolymeric resveratrol conjugates |
| title_full | Synthesis and characterization of novel copolymeric resveratrol conjugates |
| title_fullStr | Synthesis and characterization of novel copolymeric resveratrol conjugates |
| title_full_unstemmed | Synthesis and characterization of novel copolymeric resveratrol conjugates |
| title_short | Synthesis and characterization of novel copolymeric resveratrol conjugates |
| title_sort | synthesis and characterization of novel copolymeric resveratrol conjugates |
| url | http://hdl.handle.net/20.500.11937/45196 |