Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence
Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic di...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Taylor and Francis LTD
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/45163 |
| _version_ | 1848757206770515968 |
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| author | Bishayee, A. Haskell, Y. Do, C. Siveen, K. Mohandas, N. Sethi, Gautam Stoner, G. |
| author_facet | Bishayee, A. Haskell, Y. Do, C. Siveen, K. Mohandas, N. Sethi, Gautam Stoner, G. |
| author_sort | Bishayee, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed. |
| first_indexed | 2025-11-14T09:24:25Z |
| format | Journal Article |
| id | curtin-20.500.11937-45163 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:24:25Z |
| publishDate | 2016 |
| publisher | Taylor and Francis LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-451632017-09-13T14:21:31Z Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence Bishayee, A. Haskell, Y. Do, C. Siveen, K. Mohandas, N. Sethi, Gautam Stoner, G. Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed. 2016 Journal Article http://hdl.handle.net/20.500.11937/45163 10.1080/10408398.2014.982243 Taylor and Francis LTD restricted |
| spellingShingle | Bishayee, A. Haskell, Y. Do, C. Siveen, K. Mohandas, N. Sethi, Gautam Stoner, G. Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence |
| title | Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence |
| title_full | Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence |
| title_fullStr | Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence |
| title_full_unstemmed | Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence |
| title_short | Potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: Preclinical and clinical evidence |
| title_sort | potential benefits of edible berries in the management of aerodigestive and gastrointestinal tract cancers: preclinical and clinical evidence |
| url | http://hdl.handle.net/20.500.11937/45163 |