Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization
Well-defined poly[pentafluorophenyl (meth)acrylate] (PPFP(M)A) homopolymers are prepared by RAFT radical polymerization mediated by a novel chain transfer agent containing two cholesteryl groups in the R-group fragment. Subsequent reaction with a series of small-molecule amines in the presence of an...
| Main Authors: | , , |
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| Format: | Journal Article |
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Wiley - V C H Verlag GmbH & Co. KGaA
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/4506 |
| _version_ | 1848744534795616256 |
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| author | Roth, Peter Davis, T. Lowe, A. |
| author_facet | Roth, Peter Davis, T. Lowe, A. |
| author_sort | Roth, Peter |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Well-defined poly[pentafluorophenyl (meth)acrylate] (PPFP(M)A) homopolymers are prepared by RAFT radical polymerization mediated by a novel chain transfer agent containing two cholesteryl groups in the R-group fragment. Subsequent reaction with a series of small-molecule amines in the presence of an appropriate Michael acceptor for ω-group end-capping yields a library of novel bischolesteryl functional hydrophilic homopolymers. Two examples of statistical copolymers are also prepared including a biologically relevant sugar derivative. Specific examples of these homopolymers are examined with respect to their ability to self assemble in aqueous media—a process driven entirely by the cholesteryl end groups. In all instances evaluated, and under the preparation conditions examined, the homopolymers aggregate clearly forming polymersomes spanning an impressive size range. |
| first_indexed | 2025-11-14T06:03:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-4506 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:03:00Z |
| publishDate | 2014 |
| publisher | Wiley - V C H Verlag GmbH & Co. KGaA |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-45062019-02-19T05:34:53Z Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization Roth, Peter Davis, T. Lowe, A. Well-defined poly[pentafluorophenyl (meth)acrylate] (PPFP(M)A) homopolymers are prepared by RAFT radical polymerization mediated by a novel chain transfer agent containing two cholesteryl groups in the R-group fragment. Subsequent reaction with a series of small-molecule amines in the presence of an appropriate Michael acceptor for ω-group end-capping yields a library of novel bischolesteryl functional hydrophilic homopolymers. Two examples of statistical copolymers are also prepared including a biologically relevant sugar derivative. Specific examples of these homopolymers are examined with respect to their ability to self assemble in aqueous media—a process driven entirely by the cholesteryl end groups. In all instances evaluated, and under the preparation conditions examined, the homopolymers aggregate clearly forming polymersomes spanning an impressive size range. 2014 Journal Article http://hdl.handle.net/20.500.11937/4506 10.1002/marc.201300889 Wiley - V C H Verlag GmbH & Co. KGaA fulltext |
| spellingShingle | Roth, Peter Davis, T. Lowe, A. Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization |
| title | Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization |
| title_full | Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization |
| title_fullStr | Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization |
| title_full_unstemmed | Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization |
| title_short | Novel α,α-Bischolesteryl Functional (Co)Polymers: RAFT Radical Polymerization Synthesis and Preliminary Solution Characterization |
| title_sort | novel α,α-bischolesteryl functional (co)polymers: raft radical polymerization synthesis and preliminary solution characterization |
| url | http://hdl.handle.net/20.500.11937/4506 |