Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test

Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test

Estrogen acts through two molecularly distinct receptors termed estrogen receptor alpha (ERa) and estrogen receptor beta (ERß) which bind estradiol with similar affinities and mediate the effects of estrogen throughout the body. ERa plays a major role in reproductive physiology and behavior, and med...

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Bibliographic Details
Main Authors: Clark, J., Alves, S., Gundlah, C., Rocha, B., Birzin, E., Cai, S., Flick, R., Hayes, E., Ho, K., Warrier, Sudha, Pai, L., Yudkovitz, J., Fleischer, R., Colwell, L., Li, S., Wilkinson, H., Schaeffer, J., Wilkening, R., Mattingly, E., Hammond, M., Rohrer, S.
Format: Journal Article
Published: 2012
Online Access:http://hdl.handle.net/20.500.11937/44992

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