Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine
AIMS To investigate the transfer of amphetamines into breast milk following their recreational use and estimate drug exposure for the breastfed infant. METHODS Two breastfeeding mothers who were occasional recreational users of intravenous amphetamines were studied. A urine sample was collected 4 h...
| Main Authors: | , , |
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| Format: | Journal Article |
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Blackwell Publishing
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/44904 |
| _version_ | 1848757134158725120 |
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| author | Bartu, Anne Dusci, L. Ilett, K. |
| author_facet | Bartu, Anne Dusci, L. Ilett, K. |
| author_sort | Bartu, Anne |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | AIMS To investigate the transfer of amphetamines into breast milk following their recreational use and estimate drug exposure for the breastfed infant. METHODS Two breastfeeding mothers who were occasional recreational users of intravenous amphetamines were studied. A urine sample was collected 4 h after dose, and milk samples were collected over 24 h. Drug in urine was qualitatively identified by gas chromatography-mass spectrometry and quantification in milk was by high-performance liquid chromatography. Absolute infant dose via milk was estimated. RESULTS The urines contained predominantly methylamphetamine together with smaller amounts of amphetamine. In the 24 h after dose, average concentrations in milk were 111 mg l-1 and 281 mg l-1 for methylamphetamine and 4 mg l-1 and 15 mg l-1 for amphetaminein cases 1 and 2, respectively. Absolute infant doses for methylamphetamine plus amphetamine (as methylamphetamine equivalents) were 17.5 mg kg-1 day-1 and 44.7 mg kg-1 day-1, respectively, for cases 1 and 2. CONCLUSION These limited data suggest that breastfeeding should be withheld for 48 h after recreational amphetamine use. |
| first_indexed | 2025-11-14T09:23:16Z |
| format | Journal Article |
| id | curtin-20.500.11937-44904 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:23:16Z |
| publishDate | 2009 |
| publisher | Blackwell Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-449042023-02-22T06:24:18Z Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine Bartu, Anne Dusci, L. Ilett, K. lactation amphetamine methylamphetamine absolute infant dose breastfeeding recreational drug - use AIMS To investigate the transfer of amphetamines into breast milk following their recreational use and estimate drug exposure for the breastfed infant. METHODS Two breastfeeding mothers who were occasional recreational users of intravenous amphetamines were studied. A urine sample was collected 4 h after dose, and milk samples were collected over 24 h. Drug in urine was qualitatively identified by gas chromatography-mass spectrometry and quantification in milk was by high-performance liquid chromatography. Absolute infant dose via milk was estimated. RESULTS The urines contained predominantly methylamphetamine together with smaller amounts of amphetamine. In the 24 h after dose, average concentrations in milk were 111 mg l-1 and 281 mg l-1 for methylamphetamine and 4 mg l-1 and 15 mg l-1 for amphetaminein cases 1 and 2, respectively. Absolute infant doses for methylamphetamine plus amphetamine (as methylamphetamine equivalents) were 17.5 mg kg-1 day-1 and 44.7 mg kg-1 day-1, respectively, for cases 1 and 2. CONCLUSION These limited data suggest that breastfeeding should be withheld for 48 h after recreational amphetamine use. 2009 Journal Article http://hdl.handle.net/20.500.11937/44904 10.1111/j.1365-2125.2009.03366.x Blackwell Publishing unknown |
| spellingShingle | lactation amphetamine methylamphetamine absolute infant dose breastfeeding recreational drug - use Bartu, Anne Dusci, L. Ilett, K. Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| title | Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| title_full | Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| title_fullStr | Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| title_full_unstemmed | Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| title_short | Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| title_sort | transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine |
| topic | lactation amphetamine methylamphetamine absolute infant dose breastfeeding recreational drug - use |
| url | http://hdl.handle.net/20.500.11937/44904 |