Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse
A five year old Australian stock horse in Monto, Queensland, developed neurological signs and was euthanized after a six day course of illness. Histological examination of the brain and spinal cord revealed moderate to severe, subacute, non-suppurative encephalomyelitis. Sections of spinal cord stai...
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| Format: | Journal Article |
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SAGE Publications
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/44892 |
| _version_ | 1848757130821107712 |
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| author | Gordon, A. Marbach, C. Oakey, J. Edmunds, G. Condon, K. Diviney, Sinead Williams, David Bingham, J. |
| author_facet | Gordon, A. Marbach, C. Oakey, J. Edmunds, G. Condon, K. Diviney, Sinead Williams, David Bingham, J. |
| author_sort | Gordon, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A five year old Australian stock horse in Monto, Queensland, developed neurological signs and was euthanized after a six day course of illness. Histological examination of the brain and spinal cord revealed moderate to severe, subacute, non-suppurative encephalomyelitis. Sections of spinal cord stained positively in immunohistochemistry with a flavivirus-specific monoclonal antibody. Reverse transcription-polymerase chain reaction assay targeting the envelope gene of flavivirus yielded positive results from brain, spinal cord, cerebrospinal fluid and facial nerve. A flavivirus was isolated from the cerebrum and spinal cord. Nucleotide sequences obtained from amplicons from both tissues and virus isolated in cell culture were compared with those in GenBank, and had 96-98% identity with Murray Valley encephalitis virus. The partial envelope gene sequence of the viral isolate clustered into Genotype 1, and was most closely related to a previous Queensland isolate. This is the first confirmed case of naturally-occurring equine encephalitis attributable to Murray Valley encephalitis virus infection. |
| first_indexed | 2025-11-14T09:23:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-44892 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:23:12Z |
| publishDate | 2012 |
| publisher | SAGE Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-448922017-09-13T14:18:23Z Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse Gordon, A. Marbach, C. Oakey, J. Edmunds, G. Condon, K. Diviney, Sinead Williams, David Bingham, J. Murray Valley encephalitis virus flavivirus horses Encephalitis A five year old Australian stock horse in Monto, Queensland, developed neurological signs and was euthanized after a six day course of illness. Histological examination of the brain and spinal cord revealed moderate to severe, subacute, non-suppurative encephalomyelitis. Sections of spinal cord stained positively in immunohistochemistry with a flavivirus-specific monoclonal antibody. Reverse transcription-polymerase chain reaction assay targeting the envelope gene of flavivirus yielded positive results from brain, spinal cord, cerebrospinal fluid and facial nerve. A flavivirus was isolated from the cerebrum and spinal cord. Nucleotide sequences obtained from amplicons from both tissues and virus isolated in cell culture were compared with those in GenBank, and had 96-98% identity with Murray Valley encephalitis virus. The partial envelope gene sequence of the viral isolate clustered into Genotype 1, and was most closely related to a previous Queensland isolate. This is the first confirmed case of naturally-occurring equine encephalitis attributable to Murray Valley encephalitis virus infection. 2012 Journal Article http://hdl.handle.net/20.500.11937/44892 10.1177/1040638711433325 SAGE Publications fulltext |
| spellingShingle | Murray Valley encephalitis virus flavivirus horses Encephalitis Gordon, A. Marbach, C. Oakey, J. Edmunds, G. Condon, K. Diviney, Sinead Williams, David Bingham, J. Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse |
| title | Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse |
| title_full | Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse |
| title_fullStr | Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse |
| title_full_unstemmed | Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse |
| title_short | Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse |
| title_sort | confirmed case of encephalitis caused by murray valley encephalitis virus infection in a horse |
| topic | Murray Valley encephalitis virus flavivirus horses Encephalitis |
| url | http://hdl.handle.net/20.500.11937/44892 |