Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs

Chemokine–glycosaminoglycan (GAG) interactions are thought to result in the formation of tissue-bound chemokine gradients. We hypothesized that the binding of chemokines to GAGs would increase neutrophil migration toward CXC chemokines instilled into lungs of mice. To test this hypothesis we compare...

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Bibliographic Details
Main Authors: Tanino, Y., Coombe, Deirdre, Gill, S., Kett, Warren, Kajikawa, O., Proudfoot, A., Wells, T., Parks, W., Wight, T., Martin, T., Frevert, C.
Format: Journal Article
Published: American Association of Immunologists 2010
Subjects:
inflammation
Chemokine
lungs
neutrophils
glycosaminoglycan
Online Access:http://hdl.handle.net/20.500.11937/44788

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