Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis
Copyright: #x000a9; 2015 McGuire et al. A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritonea...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Public Library of Science
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/44657 |
| _version_ | 1848757064350826496 |
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| author | McGuire, A. Bennett, S. Lansley, S. Popowicz, N. Della Vergiliana, J. Wong, D. Lee, Y. Chakera, Aron |
| author_facet | McGuire, A. Bennett, S. Lansley, S. Popowicz, N. Della Vergiliana, J. Wong, D. Lee, Y. Chakera, Aron |
| author_sort | McGuire, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Copyright: #x000a9; 2015 McGuire et al. A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effectiveness of antimicrobial agents and predispose to recurrence or relapse of infection. Strategies to enhance responses to antimicrobial agents therefore have the potential to improve patient outcomes. This study presents pre-clinical data describing the compatibility of tPA and DNase in combination with antimicrobial agents used for the treatment of PD peritonitis. tPA and DNase were stable in standard dialysate solution and in the presence of antimicrobial agents, and were safe when given intraperitoneally in a mouse model with no evidence of local or systemic toxicity. Adjunctive tPA and DNase may have a role in the management of patients presenting with PD peritonitis. |
| first_indexed | 2025-11-14T09:22:09Z |
| format | Journal Article |
| id | curtin-20.500.11937-44657 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:22:09Z |
| publishDate | 2015 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-446572017-09-13T14:12:16Z Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis McGuire, A. Bennett, S. Lansley, S. Popowicz, N. Della Vergiliana, J. Wong, D. Lee, Y. Chakera, Aron Copyright: #x000a9; 2015 McGuire et al. A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effectiveness of antimicrobial agents and predispose to recurrence or relapse of infection. Strategies to enhance responses to antimicrobial agents therefore have the potential to improve patient outcomes. This study presents pre-clinical data describing the compatibility of tPA and DNase in combination with antimicrobial agents used for the treatment of PD peritonitis. tPA and DNase were stable in standard dialysate solution and in the presence of antimicrobial agents, and were safe when given intraperitoneally in a mouse model with no evidence of local or systemic toxicity. Adjunctive tPA and DNase may have a role in the management of patients presenting with PD peritonitis. 2015 Journal Article http://hdl.handle.net/20.500.11937/44657 10.1371/journal.pone.0119238 Public Library of Science unknown |
| spellingShingle | McGuire, A. Bennett, S. Lansley, S. Popowicz, N. Della Vergiliana, J. Wong, D. Lee, Y. Chakera, Aron Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis |
| title | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis |
| title_full | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis |
| title_fullStr | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis |
| title_full_unstemmed | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis |
| title_short | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis |
| title_sort | preclinical assessment of adjunctive tpa and dnase for peritoneal dialysis associated peritonitis |
| url | http://hdl.handle.net/20.500.11937/44657 |