Projections from the lateral vestibular nucleus to the spinal cord in the mouse

The present study investigated the projections from the lateral vestibular nucleus (LVe) to the spinal cord using retrograde and anterograde tracers. Retrogradely labeled neurons were found after fluoro-gold injections into both the cervical and lumbar cord, with a smaller number of labeled neurons...

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Main Authors: Liang, H., Bácskai, T., Watson, Charles, Paxinos, G.
Format: Journal Article
Published: Springer 2013
Subjects:
Online Access:http://hdl.handle.net/20.500.11937/44489
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author Liang, H.
Bácskai, T.
Watson, Charles
Paxinos, G.
author_facet Liang, H.
Bácskai, T.
Watson, Charles
Paxinos, G.
author_sort Liang, H.
building Curtin Institutional Repository
collection Online Access
description The present study investigated the projections from the lateral vestibular nucleus (LVe) to the spinal cord using retrograde and anterograde tracers. Retrogradely labeled neurons were found after fluoro-gold injections into both the cervical and lumbar cord, with a smaller number of labeled neurons seen after lumbar cord injections. Labeled neurons in the LVe were found in clusters at caudal levels of the nucleus, and a small gap separated these clusters from labeled neurons in the spinal vestibular nucleus (SpVe). In the anterograde study, BDA-labeled fiber tracts were found in both the ventral and ventrolateral funiculi on the ipsilateral side. These fibers terminated in laminae 6–9. Some fibers were continuous with boutons in contact with motor neurons in both the medial and lateral motor neuron columns. In the lumbar and sacral segments, some collaterals from the ipsilateral vestibulospinal tracts were found on the contralateral side, and these fibers mainly terminated in laminae 6–8. The present study reveals for the first time the fiber terminations of the lateral vestibular nucleus in the mouse spinal cord and therefore enhances future functional studies of the vestibulospinal system.
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spelling curtin-20.500.11937-444892017-09-13T14:11:35Z Projections from the lateral vestibular nucleus to the spinal cord in the mouse Liang, H. Bácskai, T. Watson, Charles Paxinos, G. Motor neurons Spinal cord Vestibular system Vestibulospinal tract Hindbrain The present study investigated the projections from the lateral vestibular nucleus (LVe) to the spinal cord using retrograde and anterograde tracers. Retrogradely labeled neurons were found after fluoro-gold injections into both the cervical and lumbar cord, with a smaller number of labeled neurons seen after lumbar cord injections. Labeled neurons in the LVe were found in clusters at caudal levels of the nucleus, and a small gap separated these clusters from labeled neurons in the spinal vestibular nucleus (SpVe). In the anterograde study, BDA-labeled fiber tracts were found in both the ventral and ventrolateral funiculi on the ipsilateral side. These fibers terminated in laminae 6–9. Some fibers were continuous with boutons in contact with motor neurons in both the medial and lateral motor neuron columns. In the lumbar and sacral segments, some collaterals from the ipsilateral vestibulospinal tracts were found on the contralateral side, and these fibers mainly terminated in laminae 6–8. The present study reveals for the first time the fiber terminations of the lateral vestibular nucleus in the mouse spinal cord and therefore enhances future functional studies of the vestibulospinal system. 2013 Journal Article http://hdl.handle.net/20.500.11937/44489 10.1007/s00429-013-0536-4 Springer restricted
spellingShingle Motor neurons
Spinal cord
Vestibular system
Vestibulospinal tract
Hindbrain
Liang, H.
Bácskai, T.
Watson, Charles
Paxinos, G.
Projections from the lateral vestibular nucleus to the spinal cord in the mouse
title Projections from the lateral vestibular nucleus to the spinal cord in the mouse
title_full Projections from the lateral vestibular nucleus to the spinal cord in the mouse
title_fullStr Projections from the lateral vestibular nucleus to the spinal cord in the mouse
title_full_unstemmed Projections from the lateral vestibular nucleus to the spinal cord in the mouse
title_short Projections from the lateral vestibular nucleus to the spinal cord in the mouse
title_sort projections from the lateral vestibular nucleus to the spinal cord in the mouse
topic Motor neurons
Spinal cord
Vestibular system
Vestibulospinal tract
Hindbrain
url http://hdl.handle.net/20.500.11937/44489