Synthesis and antimalarial evaluation of novel isocryptolepine derivatives

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Synthesis and antimalarial evaluation of novel isocryptolepine derivatives

A series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells). Di-halogenated compounds were the most potent der...

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Bibliographic Details
Main Authors:	Whittell, Louise, Batty, Kevin, Wong, R., Bolitho, Erin, Fox, Simon, Davis, T., Murray, Paul
Format:	Journal Article
Published:	Elsevier 2011
Online Access:	http://hdl.handle.net/20.500.11937/44272

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