Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration

Background: The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between hei...

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Main Authors: Batty, G., Barzi, F., Woodward, M., Jamrozik, K., Woo, J., Kim, H., Ueshima, H., Huxley, Rachel
Format: Journal Article
Published: Oxford University Press 2009
Online Access:http://hdl.handle.net/20.500.11937/44149
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author Batty, G.
Barzi, F.
Woodward, M.
Jamrozik, K.
Woo, J.
Kim, H.
Ueshima, H.
Huxley, Rachel
author_facet Batty, G.
Barzi, F.
Woodward, M.
Jamrozik, K.
Woo, J.
Kim, H.
Ueshima, H.
Huxley, Rachel
author_sort Batty, G.
building Curtin Institutional Repository
collection Online Access
description Background: The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between height and a series of malignancies in Australasian (Caucasian) and Asian populations. Methods: Analyses were based on the Asia Pacific Cohort Studies Collaboration of 506 648 study participants (408 381 Asia, 98 267 Australasia) drawn from 38 population-based cohort studies. Cox proportional hazards regression was used to estimate the relationship between height and cancer rates. Results: A total of 3 272 600 person-years of follow-up gave rise to 7497 cancer deaths (4415 in Asia; 3082 in Australasia). After multiple adjustments and left censoring, taller individuals experienced increased rates of carcinoma of the intestine (men and women); all cancers, liver, lung, breast, 'other' malignancies (all women); and cancers of the prostate and bladder (men). No consistent regional (Asia versus Australasia) or sex differences were observed. Conclusions: In the present study, taller men and women had an elevated risk of selected malignancies. These associations did not differ appreciably between Asian and Caucasian populations. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
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spelling curtin-20.500.11937-441492017-09-13T14:28:47Z Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration Batty, G. Barzi, F. Woodward, M. Jamrozik, K. Woo, J. Kim, H. Ueshima, H. Huxley, Rachel Background: The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between height and a series of malignancies in Australasian (Caucasian) and Asian populations. Methods: Analyses were based on the Asia Pacific Cohort Studies Collaboration of 506 648 study participants (408 381 Asia, 98 267 Australasia) drawn from 38 population-based cohort studies. Cox proportional hazards regression was used to estimate the relationship between height and cancer rates. Results: A total of 3 272 600 person-years of follow-up gave rise to 7497 cancer deaths (4415 in Asia; 3082 in Australasia). After multiple adjustments and left censoring, taller individuals experienced increased rates of carcinoma of the intestine (men and women); all cancers, liver, lung, breast, 'other' malignancies (all women); and cancers of the prostate and bladder (men). No consistent regional (Asia versus Australasia) or sex differences were observed. Conclusions: In the present study, taller men and women had an elevated risk of selected malignancies. These associations did not differ appreciably between Asian and Caucasian populations. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. 2009 Journal Article http://hdl.handle.net/20.500.11937/44149 10.1093/annonc/mdp363 Oxford University Press unknown
spellingShingle Batty, G.
Barzi, F.
Woodward, M.
Jamrozik, K.
Woo, J.
Kim, H.
Ueshima, H.
Huxley, Rachel
Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration
title Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration
title_full Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration
title_fullStr Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration
title_full_unstemmed Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration
title_short Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration
title_sort adult height and cancer mortality in asia: the asia pacific cohort studies collaboration
url http://hdl.handle.net/20.500.11937/44149