Toxicodynamic Evaluation of a Cisplatin-Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells

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Toxicodynamic Evaluation of a Cisplatin-Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells

Cisplatin (CDDP) is an anticancer drug. The clinical limitations associated with CDDP have stimulated the development of macromolecular drug-carrier systems, in attempts to decrease its toxicity. A complex (CDDP-CSA-23) between CDDP and chondroitin sulfate (CSA), a natural polysaccharide with a mean...

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Bibliographic Details
Main Authors:	Zhang, J., Kadowaki, D., Nonoguchi, H., Hirata, S., Seo, H., Imai, T., Suenaga, A., Chuang, Victor, Otagiri, M.
Format:	Journal Article
Published:	Informa Healthcare 2011
Subjects:	nephrotoxicity human proximal tubular cells complexation Chondroitin sulfate cytotoxicity cisplatin perfused kidney
Online Access:	http://hdl.handle.net/20.500.11937/44056

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