Cystine accumulation attenuates insulin release from the pancreatic beta-cell due to elevated oxidative stress and decreased ATP levels.

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Cystine accumulation attenuates insulin release from the pancreatic beta-cell due to elevated oxidative stress and decreased ATP levels.

The pancreatic beta-cell has reduced antioxidant defences making it more susceptible to oxidative stress. In cystinosis, a lysosomal storage disorder, an altered redox state may contribute to cellular dysfunction. This rare disease is caused by an abnormal lysosomal cystine transporter, cystinosin,...

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Bibliographic Details
Main Authors:	McEvoy, B., Sumayao, R., Slattery, C., McMorrow, T., Newsholme, Philip
Format:	Journal Article
Published:	2015
Online Access:	http://hdl.handle.net/20.500.11937/44049

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