Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry
A solid-phase extraction (SPE) LC/MS/MS method for 18 commercial drugs in secondary wastewaterand product water from water recycling plants using microfiltration (MF) and reverse osmosis (RO)has been developed, optimised and validated. The method incorporates a range of multi-class pharmaceuticals i...
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| Format: | Journal Article |
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Elsevier
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/44005 |
| _version_ | 1848756874394992640 |
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| author | Busetti, Francesco Linge, Kathryn Heitz, Anna |
| author_facet | Busetti, Francesco Linge, Kathryn Heitz, Anna |
| author_sort | Busetti, Francesco |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A solid-phase extraction (SPE) LC/MS/MS method for 18 commercial drugs in secondary wastewaterand product water from water recycling plants using microfiltration (MF) and reverse osmosis (RO)has been developed, optimised and validated. The method incorporates a range of multi-class pharmaceuticals including lipid lowering agents, analgesics, antipyretics, non-steroidal anti-inflammatory drugs, antidepressants, anticoagulants, tranquilizers, cytostatic agents, and antiepileptics. Method limits of quantitation (MLQs) in secondary wastewater ranged from 15 to 250 ng/L, while MLQs in post-RO water ranged from1 to 25 ng/L. Results fromanalysis of secondary waste water from Western Australia are presented, and represent the largest survey of non-antibiotic pharmaceuticals within Australia to date. Analysis of post-RO water from two MF/RO water recycling facilities also demonstrate that MF/RO treatment removes most pharmaceuticals to below the analytical limits of detection, and more importantly, up to seven orders of magnitude below health-based guideline values. |
| first_indexed | 2025-11-14T09:19:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-44005 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:19:08Z |
| publishDate | 2009 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-440052017-09-13T16:05:30Z Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry Busetti, Francesco Linge, Kathryn Heitz, Anna LC-MS wastewater water reuse pharmaceuticals indirect potable reuse systems solid-phase extraction (SPE) reverse osmosis A solid-phase extraction (SPE) LC/MS/MS method for 18 commercial drugs in secondary wastewaterand product water from water recycling plants using microfiltration (MF) and reverse osmosis (RO)has been developed, optimised and validated. The method incorporates a range of multi-class pharmaceuticals including lipid lowering agents, analgesics, antipyretics, non-steroidal anti-inflammatory drugs, antidepressants, anticoagulants, tranquilizers, cytostatic agents, and antiepileptics. Method limits of quantitation (MLQs) in secondary wastewater ranged from 15 to 250 ng/L, while MLQs in post-RO water ranged from1 to 25 ng/L. Results fromanalysis of secondary waste water from Western Australia are presented, and represent the largest survey of non-antibiotic pharmaceuticals within Australia to date. Analysis of post-RO water from two MF/RO water recycling facilities also demonstrate that MF/RO treatment removes most pharmaceuticals to below the analytical limits of detection, and more importantly, up to seven orders of magnitude below health-based guideline values. 2009 Journal Article http://hdl.handle.net/20.500.11937/44005 10.1016/j.chroma.2009.06.001 Elsevier restricted |
| spellingShingle | LC-MS wastewater water reuse pharmaceuticals indirect potable reuse systems solid-phase extraction (SPE) reverse osmosis Busetti, Francesco Linge, Kathryn Heitz, Anna Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| title | Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| title_full | Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| title_fullStr | Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| title_full_unstemmed | Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| title_short | Analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| title_sort | analysis of pharmaceuticals in indirect potable reuse systems using solid-phase extraction and liquid chromatography-tandem mass spectrometry |
| topic | LC-MS wastewater water reuse pharmaceuticals indirect potable reuse systems solid-phase extraction (SPE) reverse osmosis |
| url | http://hdl.handle.net/20.500.11937/44005 |