Akt/protein kinase B in skeletal muscle physiology and pathology
The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/43812 |
| _version_ | 1848756815375892480 |
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| author | Wu, M. Falasca, Marco Blough, E. |
| author_facet | Wu, M. Falasca, Marco Blough, E. |
| author_sort | Wu, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer. |
| first_indexed | 2025-11-14T09:18:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-43812 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:18:12Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-438122017-09-13T13:41:45Z Akt/protein kinase B in skeletal muscle physiology and pathology Wu, M. Falasca, Marco Blough, E. The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer. 2011 Journal Article http://hdl.handle.net/20.500.11937/43812 10.1002/jcp.22353 restricted |
| spellingShingle | Wu, M. Falasca, Marco Blough, E. Akt/protein kinase B in skeletal muscle physiology and pathology |
| title | Akt/protein kinase B in skeletal muscle physiology and pathology |
| title_full | Akt/protein kinase B in skeletal muscle physiology and pathology |
| title_fullStr | Akt/protein kinase B in skeletal muscle physiology and pathology |
| title_full_unstemmed | Akt/protein kinase B in skeletal muscle physiology and pathology |
| title_short | Akt/protein kinase B in skeletal muscle physiology and pathology |
| title_sort | akt/protein kinase b in skeletal muscle physiology and pathology |
| url | http://hdl.handle.net/20.500.11937/43812 |