Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age
Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potentia...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/43683 |
| _version_ | 1848756773597478912 |
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| author | Lian, I. Langaas, M. Moses, Eric Johansson, A. |
| author_facet | Lian, I. Langaas, M. Moses, Eric Johansson, A. |
| author_sort | Lian, I. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potential bias since gestational age has been shown to dramatically influence gene expression in utero-placental tissue. By pooling data from three genome-wide transcription studies of the maternal-fetal interface, we have evaluated the relative effect of gestational age and PE on gene expression. A total of 18,180 transcripts were evaluated in 49 PE cases and 105 controls, with gestational age ranging from week 14 to 42. A total of 22 transcripts were associated with PE, whereas 92 transcripts with gestational age (nominal P value <1.51*10-6, Bonferroni adjusted P value <0.05). Our results indicate that gestational age has a great influence on gene expression both in normal and PE-complicated pregnancies. This effect might introduce serious bias in data analyses and needs to be carefully assessed in future genome-wide transcription studies. © 2013 Lian et al. |
| first_indexed | 2025-11-14T09:17:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-43683 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:17:32Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-436832017-09-13T13:37:33Z Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age Lian, I. Langaas, M. Moses, Eric Johansson, A. Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potential bias since gestational age has been shown to dramatically influence gene expression in utero-placental tissue. By pooling data from three genome-wide transcription studies of the maternal-fetal interface, we have evaluated the relative effect of gestational age and PE on gene expression. A total of 18,180 transcripts were evaluated in 49 PE cases and 105 controls, with gestational age ranging from week 14 to 42. A total of 22 transcripts were associated with PE, whereas 92 transcripts with gestational age (nominal P value <1.51*10-6, Bonferroni adjusted P value <0.05). Our results indicate that gestational age has a great influence on gene expression both in normal and PE-complicated pregnancies. This effect might introduce serious bias in data analyses and needs to be carefully assessed in future genome-wide transcription studies. © 2013 Lian et al. 2013 Journal Article http://hdl.handle.net/20.500.11937/43683 10.1371/journal.pone.0069848 unknown |
| spellingShingle | Lian, I. Langaas, M. Moses, Eric Johansson, A. Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
| title | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
| title_full | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
| title_fullStr | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
| title_full_unstemmed | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
| title_short | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
| title_sort | differential gene expression at the maternal-fetal interface in preeclampsia is influenced by gestational age |
| url | http://hdl.handle.net/20.500.11937/43683 |