Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma
Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNy) secretion...
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| Format: | Journal Article |
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Blackwell Munksgaard
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/43670 |
| _version_ | 1848756769229111296 |
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| author | Le Page, M. Goodridge, J. Zhang, Guicheng Holt, P. Sly, P. Witt, C. |
| author_facet | Le Page, M. Goodridge, J. Zhang, Guicheng Holt, P. Sly, P. Witt, C. |
| author_sort | Le Page, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNy) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma. KIR2DL4 genotypes weredetermined in two cohorts of children (n=219 and n=1356) in whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and asthma symptoms had been studied between birth and 14 years. No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma. |
| first_indexed | 2025-11-14T09:17:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-43670 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:17:28Z |
| publishDate | 2013 |
| publisher | Blackwell Munksgaard |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-436702017-09-13T13:39:38Z Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma Le Page, M. Goodridge, J. Zhang, Guicheng Holt, P. Sly, P. Witt, C. atopy asthma KIR2DL4 CD158d Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNy) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma. KIR2DL4 genotypes weredetermined in two cohorts of children (n=219 and n=1356) in whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and asthma symptoms had been studied between birth and 14 years. No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma. 2013 Journal Article http://hdl.handle.net/20.500.11937/43670 10.1111/tan.12185 Blackwell Munksgaard restricted |
| spellingShingle | atopy asthma KIR2DL4 CD158d Le Page, M. Goodridge, J. Zhang, Guicheng Holt, P. Sly, P. Witt, C. Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma |
| title | Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma |
| title_full | Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma |
| title_fullStr | Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma |
| title_full_unstemmed | Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma |
| title_short | Genetic Polymorphism of KIR2DL4 (CD158d), a Putative NK Cell Receptor for HLA-G, Does Not Influence Susceptibility to Asthma |
| title_sort | genetic polymorphism of kir2dl4 (cd158d), a putative nk cell receptor for hla-g, does not influence susceptibility to asthma |
| topic | atopy asthma KIR2DL4 CD158d |
| url | http://hdl.handle.net/20.500.11937/43670 |