Stomach-specific activation of oncogenic KRAS and STAT3-dependent inflammation cooperatively promote gastric tumorigenesis in a preclinical model

Stomach-specific activation of oncogenic KRAS and STAT3-dependent inflammation cooperatively promote gastric tumorigenesis in a preclinical model

About 5% to 10% of human gastric tumors harbor oncogenic mutations in the KRAS pathway, but their presence alone is often insufficient for inducing gastric tumorigenesis, suggesting a requirement for additional mutagenic events or microenvironmental stimuli, including inflammation. Assessing the con...

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Bibliographic Details
Main Authors: Thiem, S., Eissmann, M., Elzer, J., Jonas, A., Putoczki, T., Poh, A., Nguyen, P., Preaudet, A., Flanagan, D., Vincan, Elizabeth, Waring, P., Buchert, M., Jarnicki, A., Ernst, M.
Format: Journal Article
Published: American association for Cancer Research 2016
Online Access:http://hdl.handle.net/20.500.11937/43358

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