High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential
Current musculoskeletal imaging techniques usually target the macro-morphology of articular cartilage or use histological analysis. These techniques are able to reveal advanced osteoarthritic changes in articular cartilage but fail to give detailed information to distinguish early osteoarthritis fro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
BioMed Central
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/43206 |
| _version_ | 1848756626187616256 |
|---|---|
| author | He, B. Wu, Ping Kirk, Brett Carrino, J. Xiang, C. Xu, J. |
| author_facet | He, B. Wu, Ping Kirk, Brett Carrino, J. Xiang, C. Xu, J. |
| author_sort | He, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Current musculoskeletal imaging techniques usually target the macro-morphology of articular cartilage or use histological analysis. These techniques are able to reveal advanced osteoarthritic changes in articular cartilage but fail to give detailed information to distinguish early osteoarthritis from healthy cartilage, and this necessitates high-resolution imaging techniques measuring cells and the extracellular matrix within the multilayer structure of articular cartilage. This review provides a comprehensive exploration of the cellular components and extracellular matrix of articular cartilage as well as high-resolution imaging techniques, including magnetic resonance image, electron microscopy, confocal laser scanning microscopy, second harmonic generation microscopy, and laser scanning confocal arthroscopy, in the measurement of multilayer ultra-structures of articular cartilage. This review also provides an overview for micro-structural analysis of the main components of normal or osteoarthritic cartilage and discusses the potential and challenges associated with developing non-invasive high-resolution imaging techniques for both research and clinical diagnosis of early to late osteoarthritis. |
| first_indexed | 2025-11-14T09:15:11Z |
| format | Journal Article |
| id | curtin-20.500.11937-43206 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:15:11Z |
| publishDate | 2014 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-432062017-09-13T15:06:35Z High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential He, B. Wu, Ping Kirk, Brett Carrino, J. Xiang, C. Xu, J. MRI Multiphoton Microscopy Arthritis Confocal Microscopy Current musculoskeletal imaging techniques usually target the macro-morphology of articular cartilage or use histological analysis. These techniques are able to reveal advanced osteoarthritic changes in articular cartilage but fail to give detailed information to distinguish early osteoarthritis from healthy cartilage, and this necessitates high-resolution imaging techniques measuring cells and the extracellular matrix within the multilayer structure of articular cartilage. This review provides a comprehensive exploration of the cellular components and extracellular matrix of articular cartilage as well as high-resolution imaging techniques, including magnetic resonance image, electron microscopy, confocal laser scanning microscopy, second harmonic generation microscopy, and laser scanning confocal arthroscopy, in the measurement of multilayer ultra-structures of articular cartilage. This review also provides an overview for micro-structural analysis of the main components of normal or osteoarthritic cartilage and discusses the potential and challenges associated with developing non-invasive high-resolution imaging techniques for both research and clinical diagnosis of early to late osteoarthritis. 2014 Journal Article http://hdl.handle.net/20.500.11937/43206 10.1186/ar4506 BioMed Central fulltext |
| spellingShingle | MRI Multiphoton Microscopy Arthritis Confocal Microscopy He, B. Wu, Ping Kirk, Brett Carrino, J. Xiang, C. Xu, J. High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| title | High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| title_full | High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| title_fullStr | High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| title_full_unstemmed | High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| title_short | High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| title_sort | high-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential |
| topic | MRI Multiphoton Microscopy Arthritis Confocal Microscopy |
| url | http://hdl.handle.net/20.500.11937/43206 |