ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma
The aim of this study was to determine the influence of single nucleotide polymorphisms in the ß2-adrenoceptor gene, on the response to inhaled ß2-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 a...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Informa Healthcare
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/43182 |
| _version_ | 1848756619911888896 |
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| author | Martin, A. Zhang, Guicheng Rueter, K. Khoo, S. Bizzintino, J. Hayden, C. Geelhoed, G. Goldblatt, J. Laing, I. Le Souëf, P. |
| author_facet | Martin, A. Zhang, Guicheng Rueter, K. Khoo, S. Bizzintino, J. Hayden, C. Geelhoed, G. Goldblatt, J. Laing, I. Le Souëf, P. |
| author_sort | Martin, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The aim of this study was to determine the influence of single nucleotide polymorphisms in the ß2-adrenoceptor gene, on the response to inhaled ß2-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to ß2-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for ß2Arg16Gly and ß2Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly ß2-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1hourly: 2.6hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to ß 2-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways. Copyright © 2008 Informa Healthcare USA, Inc. |
| first_indexed | 2025-11-14T09:15:05Z |
| format | Journal Article |
| id | curtin-20.500.11937-43182 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:15:05Z |
| publishDate | 2008 |
| publisher | Informa Healthcare |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-431822017-09-13T15:12:27Z ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma Martin, A. Zhang, Guicheng Rueter, K. Khoo, S. Bizzintino, J. Hayden, C. Geelhoed, G. Goldblatt, J. Laing, I. Le Souëf, P. The aim of this study was to determine the influence of single nucleotide polymorphisms in the ß2-adrenoceptor gene, on the response to inhaled ß2-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to ß2-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for ß2Arg16Gly and ß2Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly ß2-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1hourly: 2.6hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to ß 2-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways. Copyright © 2008 Informa Healthcare USA, Inc. 2008 Journal Article http://hdl.handle.net/20.500.11937/43182 10.1080/02770900801971792 Informa Healthcare restricted |
| spellingShingle | Martin, A. Zhang, Guicheng Rueter, K. Khoo, S. Bizzintino, J. Hayden, C. Geelhoed, G. Goldblatt, J. Laing, I. Le Souëf, P. ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| title | ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| title_full | ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| title_fullStr | ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| title_full_unstemmed | ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| title_short | ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| title_sort | ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma |
| url | http://hdl.handle.net/20.500.11937/43182 |