Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies
Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier Ltd
2014
|
| Online Access: | http://hdl.handle.net/20.500.11937/43138 |
| _version_ | 1848756607854313472 |
|---|---|
| author | Dingjan, T. Spendlove, I. Durrant, L. Scott, A. Yuriev, E. Ramsland, Paul |
| author_facet | Dingjan, T. Spendlove, I. Durrant, L. Scott, A. Yuriev, E. Ramsland, Paul |
| author_sort | Dingjan, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy. |
| first_indexed | 2025-11-14T09:14:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-43138 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:14:54Z |
| publishDate | 2014 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-431382017-09-13T15:12:27Z Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies Dingjan, T. Spendlove, I. Durrant, L. Scott, A. Yuriev, E. Ramsland, Paul Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy. 2014 Journal Article http://hdl.handle.net/20.500.11937/43138 10.1016/j.molimm.2015.02.028 Elsevier Ltd restricted |
| spellingShingle | Dingjan, T. Spendlove, I. Durrant, L. Scott, A. Yuriev, E. Ramsland, Paul Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| title | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| title_full | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| title_fullStr | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| title_full_unstemmed | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| title_short | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| title_sort | structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies |
| url | http://hdl.handle.net/20.500.11937/43138 |