Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa
Statins are a family of drugs that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA-reductase, a rate-limiting enzyme in the human mevalonate pathway of which cholesterol is the biosynthetic end product.1 Statins also have a range of cholesterol-independent effects, including an...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Nature Publishing Group
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/42875 |
| _version_ | 1848756538064240640 |
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| author | Hennessey, E. Mooij, M. Legendre, C. Reen, F. O'Callaghan, J. Adams, C. O'Gara, Fergal |
| author_facet | Hennessey, E. Mooij, M. Legendre, C. Reen, F. O'Callaghan, J. Adams, C. O'Gara, Fergal |
| author_sort | Hennessey, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Statins are a family of drugs that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA-reductase, a rate-limiting enzyme in the human mevalonate pathway of which cholesterol is the biosynthetic end product.1 Statins also have a range of cholesterol-independent effects, including anti-inflammatory functions and antimicrobial activity. These pleiotropic effects are thought to account for the improved survival observed in statin-treated patients suffering from severe bacterial infections, such as sepsis and pneumonia. In order to identify the mechanism involved in the protective effects of statins against infection, research studies focused on the direct effect of statins on bacteria. |
| first_indexed | 2025-11-14T09:13:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-42875 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:13:47Z |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-428752017-09-13T15:04:46Z Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa Hennessey, E. Mooij, M. Legendre, C. Reen, F. O'Callaghan, J. Adams, C. O'Gara, Fergal Statins are a family of drugs that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA-reductase, a rate-limiting enzyme in the human mevalonate pathway of which cholesterol is the biosynthetic end product.1 Statins also have a range of cholesterol-independent effects, including anti-inflammatory functions and antimicrobial activity. These pleiotropic effects are thought to account for the improved survival observed in statin-treated patients suffering from severe bacterial infections, such as sepsis and pneumonia. In order to identify the mechanism involved in the protective effects of statins against infection, research studies focused on the direct effect of statins on bacteria. 2013 Journal Article http://hdl.handle.net/20.500.11937/42875 10.1038/ja.2012.95 Nature Publishing Group restricted |
| spellingShingle | Hennessey, E. Mooij, M. Legendre, C. Reen, F. O'Callaghan, J. Adams, C. O'Gara, Fergal Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa |
| title | Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa |
| title_full | Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa |
| title_fullStr | Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa |
| title_full_unstemmed | Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa |
| title_short | Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa |
| title_sort | statins inhibit in vitro virulence phenotypes of pseudomonas aeruginosa |
| url | http://hdl.handle.net/20.500.11937/42875 |