Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolatedfrom roots and barks of numerous plants, molds, and lichens. It is found as an active ingredientin different Chinese herbs including Rheum palmatum and Polygonam multiflorum, and has diuretic,vaso...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier
2013
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/42710 |
| _version_ | 1848756494725545984 |
|---|---|
| author | Shrimali, D. Shanmugam, M. Kumar, Alan Prem Zhang, J. Tan, B. Ahn, K. Sethi, G. |
| author_facet | Shrimali, D. Shanmugam, M. Kumar, Alan Prem Zhang, J. Tan, B. Ahn, K. Sethi, G. |
| author_sort | Shrimali, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolatedfrom roots and barks of numerous plants, molds, and lichens. It is found as an active ingredientin different Chinese herbs including Rheum palmatum and Polygonam multiflorum, and has diuretic,vasorelaxant, anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. Theanti-inflammatory effects of emodin have been exhibited in various in vitro as well as in vivo modelsof inflammation including pancreatitis, arthritis, asthma, atherosclerosis and glomerulonephritis. As ananti-cancer agent, emodin has been shown to suppress the growth of various tumor cell lines includinghepatocellular carcinoma, pancreatic, breast, colorectal, leukemia, and lung cancers. Emodin is a pleiotropicmolecule capable of interacting with several major molecular targets including NF-jB, casein kinaseII, HER2/neu, HIF-1a, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptorswhich are involved in inflammation and cancer. This review summarizes reported anti-inflammatoryand anti-cancer effects of emodin, and re-emphasizes its potential therapeutic role in the treatment ofinflammatory diseases and cancer. |
| first_indexed | 2025-11-14T09:13:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-42710 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:13:06Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-427102018-03-29T09:07:46Z Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer Shrimali, D. Shanmugam, M. Kumar, Alan Prem Zhang, J. Tan, B. Ahn, K. Sethi, G. Apoptosis Emodin Angiogenesis Cancer Metastasis Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolatedfrom roots and barks of numerous plants, molds, and lichens. It is found as an active ingredientin different Chinese herbs including Rheum palmatum and Polygonam multiflorum, and has diuretic,vasorelaxant, anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. Theanti-inflammatory effects of emodin have been exhibited in various in vitro as well as in vivo modelsof inflammation including pancreatitis, arthritis, asthma, atherosclerosis and glomerulonephritis. As ananti-cancer agent, emodin has been shown to suppress the growth of various tumor cell lines includinghepatocellular carcinoma, pancreatic, breast, colorectal, leukemia, and lung cancers. Emodin is a pleiotropicmolecule capable of interacting with several major molecular targets including NF-jB, casein kinaseII, HER2/neu, HIF-1a, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptorswhich are involved in inflammation and cancer. This review summarizes reported anti-inflammatoryand anti-cancer effects of emodin, and re-emphasizes its potential therapeutic role in the treatment ofinflammatory diseases and cancer. 2013 Journal Article http://hdl.handle.net/20.500.11937/42710 10.1016/j.canlet.2013.08.023 Elsevier restricted |
| spellingShingle | Apoptosis Emodin Angiogenesis Cancer Metastasis Shrimali, D. Shanmugam, M. Kumar, Alan Prem Zhang, J. Tan, B. Ahn, K. Sethi, G. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| title | Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| title_full | Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| title_fullStr | Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| title_full_unstemmed | Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| title_short | Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| title_sort | targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer |
| topic | Apoptosis Emodin Angiogenesis Cancer Metastasis |
| url | http://hdl.handle.net/20.500.11937/42710 |