Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2)
© 2015 European Society of Cardiology. Aims: Hypertension is a known risk factor for the development of heart failure (HF); however, few data are available on the magnitude of short- and long-term progression from hypertension to HF. The present study aims to determine the short- and long-term incid...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/4266 |
| _version_ | 1848744467500105728 |
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| author | Sahle, B. Owen, A. Krum, H. Reid, Christopher |
| author_facet | Sahle, B. Owen, A. Krum, H. Reid, Christopher |
| author_sort | Sahle, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2015 European Society of Cardiology. Aims: Hypertension is a known risk factor for the development of heart failure (HF); however, few data are available on the magnitude of short- and long-term progression from hypertension to HF. The present study aims to determine the short- and long-term incidence of HF, and identify factors associated with onset of HF in elderly hypertensive patients. Methods and results: The incidence of HF was measured in 6083 hypertensive patients, in the Second Australian National Blood Pressure Study (ANBP2), followed for a median of 10.8years (4.1years during the trial and 6.7years during post-trial follow-up). A total of 373 cases of HF were identified over 59 581 person-years of follow-up (PY). The overall cumulative incidence of HF was 6.26 per 1000 PY; 5.33 per 1000 PY during the ANBP2 clinical trial and 7.04 per 1000 PY during the post-trial follow-up. HF was 63% higher among men [incidence rate ratios (IRR) 1.63, P<0.01]. Older age, male sex, obesity, and history of cardiovascular disease independently predicted HF during both the short- and long-term follow-up. In addition, diabetes and smoking were associated with onset of HF in the short-term follow-up, and higher systolic blood pressure in the long-term follow-up. Median survival following diagnosis with HF was 3.94years, and women (6.06years) had a survival advantage over men (3.32years). Conclusion: Heart failure is a frequent long-term outcome in treated elderly hypertensive patients. Development of HF was predicted by patient characteristics and co-morbidities, with the effect of some predictors varying over the short- and long-term follow-up. |
| first_indexed | 2025-11-14T06:01:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-4266 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:01:56Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-42662017-09-13T14:47:32Z Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) Sahle, B. Owen, A. Krum, H. Reid, Christopher © 2015 European Society of Cardiology. Aims: Hypertension is a known risk factor for the development of heart failure (HF); however, few data are available on the magnitude of short- and long-term progression from hypertension to HF. The present study aims to determine the short- and long-term incidence of HF, and identify factors associated with onset of HF in elderly hypertensive patients. Methods and results: The incidence of HF was measured in 6083 hypertensive patients, in the Second Australian National Blood Pressure Study (ANBP2), followed for a median of 10.8years (4.1years during the trial and 6.7years during post-trial follow-up). A total of 373 cases of HF were identified over 59 581 person-years of follow-up (PY). The overall cumulative incidence of HF was 6.26 per 1000 PY; 5.33 per 1000 PY during the ANBP2 clinical trial and 7.04 per 1000 PY during the post-trial follow-up. HF was 63% higher among men [incidence rate ratios (IRR) 1.63, P<0.01]. Older age, male sex, obesity, and history of cardiovascular disease independently predicted HF during both the short- and long-term follow-up. In addition, diabetes and smoking were associated with onset of HF in the short-term follow-up, and higher systolic blood pressure in the long-term follow-up. Median survival following diagnosis with HF was 3.94years, and women (6.06years) had a survival advantage over men (3.32years). Conclusion: Heart failure is a frequent long-term outcome in treated elderly hypertensive patients. Development of HF was predicted by patient characteristics and co-morbidities, with the effect of some predictors varying over the short- and long-term follow-up. 2015 Journal Article http://hdl.handle.net/20.500.11937/4266 10.1002/ejhf.427 unknown |
| spellingShingle | Sahle, B. Owen, A. Krum, H. Reid, Christopher Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) |
| title | Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) |
| title_full | Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) |
| title_fullStr | Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) |
| title_full_unstemmed | Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) |
| title_short | Incidence of heart failure in 6083 elderly hypertensive patients: The Second Australian National Blood Pressure Study (ANBP2) |
| title_sort | incidence of heart failure in 6083 elderly hypertensive patients: the second australian national blood pressure study (anbp2) |
| url | http://hdl.handle.net/20.500.11937/4266 |