Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images
The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the ver...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Academic Press
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/42580 |
| _version_ | 1848756459105419264 |
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| author | Ullmann, J. Keller, M. Watson, Charles Jenke, A. Kurniawan, N. Yang, Z. Richards, K. Paxinos, G. Egan, G. Petrou, S. Bartlett, P. Galloway, J. Reutens, D. |
| author_facet | Ullmann, J. Keller, M. Watson, Charles Jenke, A. Kurniawan, N. Yang, Z. Richards, K. Paxinos, G. Egan, G. Petrou, S. Bartlett, P. Galloway, J. Reutens, D. |
| author_sort | Ullmann, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the vermal and hemispheric lobules of the C57BL/6J mouse cerebellum in magnetic resonance images. We have successfully delineated 38 cerebellar and cerebellar-related structures. The higher signal-to-noise ratio achieved by group averaging facilitated the identification of anatomical structures. In addition, we have calculated average region volumes and created probabilistic maps for each structure. The segmentation method and the probabilistic maps we have created will provide a foundation for future studies of cerebellar disorders using transgenic mouse models. |
| first_indexed | 2025-11-14T09:12:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-42580 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:12:32Z |
| publishDate | 2012 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-425802018-03-29T09:07:45Z Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images Ullmann, J. Keller, M. Watson, Charles Jenke, A. Kurniawan, N. Yang, Z. Richards, K. Paxinos, G. Egan, G. Petrou, S. Bartlett, P. Galloway, J. Reutens, D. The C57BL mouse is the centerpiece of efforts to use gene-targeting technology to understand cerebellar pathology, thus creating a need for a detailed magnetic resonance imaging (MRI) atlas of the cerebellum of this strain. In this study we present a methodology for systematic delineation of the vermal and hemispheric lobules of the C57BL/6J mouse cerebellum in magnetic resonance images. We have successfully delineated 38 cerebellar and cerebellar-related structures. The higher signal-to-noise ratio achieved by group averaging facilitated the identification of anatomical structures. In addition, we have calculated average region volumes and created probabilistic maps for each structure. The segmentation method and the probabilistic maps we have created will provide a foundation for future studies of cerebellar disorders using transgenic mouse models. 2012 Journal Article http://hdl.handle.net/20.500.11937/42580 10.1016/j.neuroimage.2012.05.061 Academic Press restricted |
| spellingShingle | Ullmann, J. Keller, M. Watson, Charles Jenke, A. Kurniawan, N. Yang, Z. Richards, K. Paxinos, G. Egan, G. Petrou, S. Bartlett, P. Galloway, J. Reutens, D. Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images |
| title | Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images |
| title_full | Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images |
| title_fullStr | Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images |
| title_full_unstemmed | Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images |
| title_short | Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images |
| title_sort | segmentation of the c57bl/6j mouse cerebellum in magnetic resonance images |
| url | http://hdl.handle.net/20.500.11937/42580 |