Netrin-1 in the developing enteric nervous system and colorectal cancer
Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a fa...
| Main Authors: | , , |
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| Format: | Journal Article |
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Elsevier Ltd.
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/42410 |
| _version_ | 1848756412121874432 |
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| author | Ko, S. Dass, Crispin Nurgali, K. |
| author_facet | Ko, S. Dass, Crispin Nurgali, K. |
| author_sort | Ko, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer. |
| first_indexed | 2025-11-14T09:11:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-42410 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:11:47Z |
| publishDate | 2012 |
| publisher | Elsevier Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-424102017-09-13T14:26:11Z Netrin-1 in the developing enteric nervous system and colorectal cancer Ko, S. Dass, Crispin Nurgali, K. dependence receptors DCC UNC-5H Netrin-1 enteric nervous system cell survival colorectal cancer neuronal guidance Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer. 2012 Journal Article http://hdl.handle.net/20.500.11937/42410 10.1016/j.molmed.2012.07.001 Elsevier Ltd. restricted |
| spellingShingle | dependence receptors DCC UNC-5H Netrin-1 enteric nervous system cell survival colorectal cancer neuronal guidance Ko, S. Dass, Crispin Nurgali, K. Netrin-1 in the developing enteric nervous system and colorectal cancer |
| title | Netrin-1 in the developing enteric nervous system and colorectal cancer |
| title_full | Netrin-1 in the developing enteric nervous system and colorectal cancer |
| title_fullStr | Netrin-1 in the developing enteric nervous system and colorectal cancer |
| title_full_unstemmed | Netrin-1 in the developing enteric nervous system and colorectal cancer |
| title_short | Netrin-1 in the developing enteric nervous system and colorectal cancer |
| title_sort | netrin-1 in the developing enteric nervous system and colorectal cancer |
| topic | dependence receptors DCC UNC-5H Netrin-1 enteric nervous system cell survival colorectal cancer neuronal guidance |
| url | http://hdl.handle.net/20.500.11937/42410 |