Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia
Owing to the high rates of malignant mesothelioma in workers exposed to crocidolite earlier at Wittenoom and evidence of protection against cancer by vitamin A, a population-based cancer prevention programme providing retinol supplements (25,000 IU/day) was commenced in 1990. The former workers at W...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Lippincott Williams & Wilkins
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/42392 |
| _version_ | 1848756407291084800 |
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| author | Alfonso, Helman Reid, Alison De Klerk, N. Olsen, N. Mina, R. Ambrosini, G. Beilby, J. Berry, G. Musk, B. |
| author_facet | Alfonso, Helman Reid, Alison De Klerk, N. Olsen, N. Mina, R. Ambrosini, G. Beilby, J. Berry, G. Musk, B. |
| author_sort | Alfonso, Helman |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Owing to the high rates of malignant mesothelioma in workers exposed to crocidolite earlier at Wittenoom and evidence of protection against cancer by vitamin A, a population-based cancer prevention programme providing retinol supplements (25,000 IU/day) was commenced in 1990. The former workers at Wittenoom known to be alive and living in Western Australia in June 1990 constitute the study population. The participants were classified into two groups: those who received supplemental retinol (intervention group) and those who received none (comparison group). The relative rate of mesothelioma for those receiving retinol was estimated using Cox regression, adjusting for cumulative asbestos exposure and age at first exposure to asbestos. Nine hundred and twenty-eight former Wittenoom workers received retinol at some stage of the programme, whereas 1471 workers never received retinol (comparison group). Those who received retinol were younger, had a greater exposure to asbestos and smoked less than the comparison group. There were 65 cases of mesothelioma in the retinol group and 88 in the comparison group. After adjustment, the hazard ratio was 0.99 (95% confidence interval=0.70-1.41). This result did not alter when the participants who received only retinol once or those who received ß-carotene earlier were excluded from the analysis. In conclusion, this study provides little support for possible preventive effects of retinol against mesothelioma in workers exposed to blue asbestos. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| first_indexed | 2025-11-14T09:11:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-42392 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:11:42Z |
| publishDate | 2010 |
| publisher | Lippincott Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-423922017-09-13T14:23:35Z Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia Alfonso, Helman Reid, Alison De Klerk, N. Olsen, N. Mina, R. Ambrosini, G. Beilby, J. Berry, G. Musk, B. Owing to the high rates of malignant mesothelioma in workers exposed to crocidolite earlier at Wittenoom and evidence of protection against cancer by vitamin A, a population-based cancer prevention programme providing retinol supplements (25,000 IU/day) was commenced in 1990. The former workers at Wittenoom known to be alive and living in Western Australia in June 1990 constitute the study population. The participants were classified into two groups: those who received supplemental retinol (intervention group) and those who received none (comparison group). The relative rate of mesothelioma for those receiving retinol was estimated using Cox regression, adjusting for cumulative asbestos exposure and age at first exposure to asbestos. Nine hundred and twenty-eight former Wittenoom workers received retinol at some stage of the programme, whereas 1471 workers never received retinol (comparison group). Those who received retinol were younger, had a greater exposure to asbestos and smoked less than the comparison group. There were 65 cases of mesothelioma in the retinol group and 88 in the comparison group. After adjustment, the hazard ratio was 0.99 (95% confidence interval=0.70-1.41). This result did not alter when the participants who received only retinol once or those who received ß-carotene earlier were excluded from the analysis. In conclusion, this study provides little support for possible preventive effects of retinol against mesothelioma in workers exposed to blue asbestos. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. 2010 Journal Article http://hdl.handle.net/20.500.11937/42392 10.1097/CEJ.0b013e32833c1bcb Lippincott Williams & Wilkins restricted |
| spellingShingle | Alfonso, Helman Reid, Alison De Klerk, N. Olsen, N. Mina, R. Ambrosini, G. Beilby, J. Berry, G. Musk, B. Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia |
| title | Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia |
| title_full | Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia |
| title_fullStr | Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia |
| title_full_unstemmed | Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia |
| title_short | Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia |
| title_sort | retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (crocidolite) at wittenoom, western australia |
| url | http://hdl.handle.net/20.500.11937/42392 |