The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones

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The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones

The heat-shock protein 90 (Hsp90) cochaperone FK506-binding protein 52 (FKBP52) upregulates, whereas FKBP51 inhibits, hormone binding and nuclear targeting of the glucocorticoid receptor (GR). Decreased cortisol sensitivity in the guinea pig is attributed to changes within the helix 1 to helix 3 (H1...

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Bibliographic Details
Main Authors:	Cluning, C., Ward, B., Rea, S., Arulpragasam, Ajanthy, Fuller, P., Ratajczak, T.
Format:	Journal Article
Published:	2013
Online Access:	http://hdl.handle.net/20.500.11937/42325

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