Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have revealed mutations in various genes encoding proteins in the NF-B pathway that contribute to the activated B-cell (ABC) DLBCL subtype, but thu...

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Bibliographic Details
Main Authors: Morin, R., Johnson, N., Severson, T., Mungall, A., An, J., Goya, R., Paul, J., Boyle, M., Woolcock, B., Kuchenbauer, F., Yap, D., Humphries, R., Griffith, O., Shah, S., Zhu, H., Kimbara, M., Shashkin, P., Charlot, J., Tcherpakov, M., Corbett, R., Tam, A., Varhol, Richard, Smailus, D., Moksa, M., Zhao, Y., Delaney, A., Qian, H., Birol, I., Schein, J., Moore, R., Holt, R., Horsman, D., Connors, J., Jones, S., Aparicio, S., Hirst, M., Gascoyne, R., Marra, M.
Format: Journal Article
Published: Nature Publishing Group 2010
Online Access:http://hdl.handle.net/20.500.11937/42144

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