Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children
Background: Infants who develop house dust mite (HDM) allergy and HDM-sensitised children with severe persistent asthma have low antibody responses to the P6 antigen of Haemophilus influenzae. Objective: To measure the development of antibody to two ubiquitous bacteria of the respiratory mucosa in a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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2012
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| Online Access: | http://hdl.handle.net/20.500.11937/41949 |
| _version_ | 1848756284688433152 |
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| author | Hales, B. Chai, L. Elliot, C. Pearce, L. Zhang, Guicheng Heinrich, T. Smith, W. Kusel, M. Holt, P. Sly, P. Thomas, W. |
| author_facet | Hales, B. Chai, L. Elliot, C. Pearce, L. Zhang, Guicheng Heinrich, T. Smith, W. Kusel, M. Holt, P. Sly, P. Thomas, W. |
| author_sort | Hales, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Infants who develop house dust mite (HDM) allergy and HDM-sensitised children with severe persistent asthma have low antibody responses to the P6 antigen of Haemophilus influenzae. Objective: To measure the development of antibody to two ubiquitous bacteria of the respiratory mucosa in a prospective birth cohort at high risk of allergic disease and to assess which responses are associated with asthma and atopy. Methods: IgG1 and IgG4 antibody to H influenzae (P4 and P6) and Streptoccocus pneumoniae (PspA and PspC) surface antigens was measured in yearly blood samples of children aged 1-5 years. IgE to the P6 antigen was examined for the 5-year group. The children were stratified based on HDM sensitisation and asthma at 5 years of age. Results: HDM-sensitised children had lower IgG1 antibody titres to the bacterial antigens, and early responses (<3 years and before the development of HDM sensitisation and asthma) corrected for multiple antigens were significantly reduced for P4, P6 and PspC (p=0.008, p=0.004 and p=0.028, respectively). Similar associations with asthma were also found (p=0.008, p=0.004 and p=0.032 for P4, P6 and PspC, respectively). The IgG4 antibody titre and prevalence were similar in both HDM-sensitised and non-sensitised groups, but sensitised children had a slower downregulation of the IgG4 response. Children with asthma (27/145 at 5 years) had lower anti-P6 IgE responses (p<0.05). Conclusions: HDM-sensitised children have early defective antibody responses to bacteria that are associated with asthma. Surprisingly, antibacterial IgE was associated with a reduced risk for asthma. |
| first_indexed | 2025-11-14T09:09:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-41949 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:09:45Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-419492017-09-13T14:21:31Z Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children Hales, B. Chai, L. Elliot, C. Pearce, L. Zhang, Guicheng Heinrich, T. Smith, W. Kusel, M. Holt, P. Sly, P. Thomas, W. Background: Infants who develop house dust mite (HDM) allergy and HDM-sensitised children with severe persistent asthma have low antibody responses to the P6 antigen of Haemophilus influenzae. Objective: To measure the development of antibody to two ubiquitous bacteria of the respiratory mucosa in a prospective birth cohort at high risk of allergic disease and to assess which responses are associated with asthma and atopy. Methods: IgG1 and IgG4 antibody to H influenzae (P4 and P6) and Streptoccocus pneumoniae (PspA and PspC) surface antigens was measured in yearly blood samples of children aged 1-5 years. IgE to the P6 antigen was examined for the 5-year group. The children were stratified based on HDM sensitisation and asthma at 5 years of age. Results: HDM-sensitised children had lower IgG1 antibody titres to the bacterial antigens, and early responses (<3 years and before the development of HDM sensitisation and asthma) corrected for multiple antigens were significantly reduced for P4, P6 and PspC (p=0.008, p=0.004 and p=0.028, respectively). Similar associations with asthma were also found (p=0.008, p=0.004 and p=0.032 for P4, P6 and PspC, respectively). The IgG4 antibody titre and prevalence were similar in both HDM-sensitised and non-sensitised groups, but sensitised children had a slower downregulation of the IgG4 response. Children with asthma (27/145 at 5 years) had lower anti-P6 IgE responses (p<0.05). Conclusions: HDM-sensitised children have early defective antibody responses to bacteria that are associated with asthma. Surprisingly, antibacterial IgE was associated with a reduced risk for asthma. 2012 Journal Article http://hdl.handle.net/20.500.11937/41949 10.1136/thoraxjnl-2011-200650 unknown |
| spellingShingle | Hales, B. Chai, L. Elliot, C. Pearce, L. Zhang, Guicheng Heinrich, T. Smith, W. Kusel, M. Holt, P. Sly, P. Thomas, W. Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| title | Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| title_full | Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| title_fullStr | Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| title_full_unstemmed | Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| title_short | Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| title_sort | antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children |
| url | http://hdl.handle.net/20.500.11937/41949 |