Validation of a chloroquine-induced cell death mechanism for clinical use against malaria

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Validation of a chloroquine-induced cell death mechanism for clinical use against malaria

An alternative antimalarial pathway of an ‘outdated’ drug, chloroquine (CQ), may facilitate its return to the shrinking list of effective antimalarials. Conventionally, CQ is believed to interfere with hemozoin formation at nanomolar concentrations, but resistant parasites are able to efflux this dr...

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Bibliographic Details
Main Authors:	Ch'ng, J., Lee, Y., Gun, S., Chia, W., Chang, Z., Wong, L., Batty, Kevin, Russell, B., Nosten, F., Renia, L., Tan, K.
Format:	Journal Article
Published:	Nature Publishing Group 2014
Online Access:	http://hdl.handle.net/20.500.11937/41899

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