The potential role of free chitosan in bone trauma and bone cancer management
Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases oste...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Elsevier Ltd
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/41787 |
| _version_ | 1848756241004756992 |
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| author | Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin |
| author_facet | Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin |
| author_sort | Tan, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collagen I expression, and reduces osteoclastogenesis. Chitosan inhibits invasion of endothelial cells, downregulating uPA/R, MT1-MMP, cdc42 and Rac1. Better healing of bone fractures with greater trabecular bone formation was observed in mice treated with chitosan. Chitosan induces apoptosis in osteotropic prostate and breast cancer cells via caspase-2 and -3 activation, and reduces their establishment in bone. Chitosan is pro-apoptotic in osteosarcoma cells, but not their normal counterpart, osteoblasts, or chondrosarcoma cells. Systemic delivery of chitosan does not perturb angiogenesis, bone volume or instinctive behaviour in pregnant mice, but decreases foetal length and changes pancreatic secretory acini. With certain controls in place, chitosan could be useful for bone trauma management. |
| first_indexed | 2025-11-14T09:09:04Z |
| format | Journal Article |
| id | curtin-20.500.11937-41787 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:09:04Z |
| publishDate | 2014 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-417872017-09-13T14:19:00Z The potential role of free chitosan in bone trauma and bone cancer management Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin Chitosan Fracture Angiogenesis Stem cell Cancer Osteogenesis Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collagen I expression, and reduces osteoclastogenesis. Chitosan inhibits invasion of endothelial cells, downregulating uPA/R, MT1-MMP, cdc42 and Rac1. Better healing of bone fractures with greater trabecular bone formation was observed in mice treated with chitosan. Chitosan induces apoptosis in osteotropic prostate and breast cancer cells via caspase-2 and -3 activation, and reduces their establishment in bone. Chitosan is pro-apoptotic in osteosarcoma cells, but not their normal counterpart, osteoblasts, or chondrosarcoma cells. Systemic delivery of chitosan does not perturb angiogenesis, bone volume or instinctive behaviour in pregnant mice, but decreases foetal length and changes pancreatic secretory acini. With certain controls in place, chitosan could be useful for bone trauma management. 2014 Journal Article http://hdl.handle.net/20.500.11937/41787 10.1016/j.biomaterials.2014.05.087 Elsevier Ltd restricted |
| spellingShingle | Chitosan Fracture Angiogenesis Stem cell Cancer Osteogenesis Tan, M. Shao, P. Friedhuber, A. van Moorst, M. Elahy, M. Indumathy, S. Dunstan, D. Wei, Y. Dass, Crispin The potential role of free chitosan in bone trauma and bone cancer management |
| title | The potential role of free chitosan in bone trauma and bone cancer management |
| title_full | The potential role of free chitosan in bone trauma and bone cancer management |
| title_fullStr | The potential role of free chitosan in bone trauma and bone cancer management |
| title_full_unstemmed | The potential role of free chitosan in bone trauma and bone cancer management |
| title_short | The potential role of free chitosan in bone trauma and bone cancer management |
| title_sort | potential role of free chitosan in bone trauma and bone cancer management |
| topic | Chitosan Fracture Angiogenesis Stem cell Cancer Osteogenesis |
| url | http://hdl.handle.net/20.500.11937/41787 |