The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis
BACKGROUND: Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE: We...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2013
|
| Online Access: | http://hdl.handle.net/20.500.11937/41523 |
| _version_ | 1848756169311518720 |
|---|---|
| author | Affandi, J. Kumar, M. Agarwal, U. Singh, S. Price, Patricia |
| author_facet | Affandi, J. Kumar, M. Agarwal, U. Singh, S. Price, Patricia |
| author_sort | Affandi, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | BACKGROUND: Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE: We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and their receptors associate with development of an IRD event in patients of two different ethnicities. METHODS: DNA samples were available from small well-characterised groups of HIV patients treated in Cambodia (TB-IRD, n=17; HIV^{+}TB^{+} controls, n=55) and India (TB-IRD, n=19; HIV^{+}TB^{+} controls, n= 43). HIV patients with a TB diagnosis but no evidence of IRD were included to control for susceptibility to TB per se. Sixteen SNP implicated in inflammation or mycobacterial disease were genotyped. RESULTS: Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964; P=0.05) and SLC11A1 D543N*G (rs17235409; P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518; P=0.02) and VDR FokI (F/f)*T (rs10735810; P=0.05) in Indian patients. CONCLUSIONS: Associations between polymorphisms in immune-related genes and TB-IRD were found, but none were common across two ethnicities. © 2013 - IOS Press and the authors. All rights reserved. |
| first_indexed | 2025-11-14T09:07:55Z |
| format | Journal Article |
| id | curtin-20.500.11937-41523 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:07:55Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-415232017-09-13T14:15:05Z The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis Affandi, J. Kumar, M. Agarwal, U. Singh, S. Price, Patricia BACKGROUND: Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE: We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and their receptors associate with development of an IRD event in patients of two different ethnicities. METHODS: DNA samples were available from small well-characterised groups of HIV patients treated in Cambodia (TB-IRD, n=17; HIV^{+}TB^{+} controls, n=55) and India (TB-IRD, n=19; HIV^{+}TB^{+} controls, n= 43). HIV patients with a TB diagnosis but no evidence of IRD were included to control for susceptibility to TB per se. Sixteen SNP implicated in inflammation or mycobacterial disease were genotyped. RESULTS: Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964; P=0.05) and SLC11A1 D543N*G (rs17235409; P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518; P=0.02) and VDR FokI (F/f)*T (rs10735810; P=0.05) in Indian patients. CONCLUSIONS: Associations between polymorphisms in immune-related genes and TB-IRD were found, but none were common across two ethnicities. © 2013 - IOS Press and the authors. All rights reserved. 2013 Journal Article http://hdl.handle.net/20.500.11937/41523 10.3233/DMA-130991 restricted |
| spellingShingle | Affandi, J. Kumar, M. Agarwal, U. Singh, S. Price, Patricia The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis |
| title | The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis |
| title_full | The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis |
| title_fullStr | The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis |
| title_full_unstemmed | The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis |
| title_short | The search for a genetic factor associating with immune restoration disease in HIV patients co-infected with Mycobacterium tuberculosis |
| title_sort | search for a genetic factor associating with immune restoration disease in hiv patients co-infected with mycobacterium tuberculosis |
| url | http://hdl.handle.net/20.500.11937/41523 |