A critical assessment of the factors affecting reporter gene assays for promoter SNP function: A reassessment of -308 TNF polymorphism function using a novel integrated reporter system

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A critical assessment of the factors affecting reporter gene assays for promoter SNP function: A reassessment of -308 TNF polymorphism function using a novel integrated reporter system

One of the greatest challenges facing genetics is the development of strategies to identify functionally relevant genetic variation. The most common test of function is the reporter gene assay, in which allelic regulatory regions are used to drive the expression of a reporter gene, and differences i...

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Bibliographic Details
Main Authors:	Karimi, M., Goldie, L., Cruickshank, M., Moses, Eric, Abraham, L.
Format:	Journal Article
Published:	Nature Publishing Group 2009
Online Access:	http://hdl.handle.net/20.500.11937/41423

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