Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus
The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNa) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fi...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Hindawi Publishing Corporation
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/41097 |
| _version_ | 1848756049865080832 |
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| author | Lee, S. Varano, J. Flexman, J. Cheng, W. Watson, M. Rossi, E. Adams, L. Bulsara, M. Price, Patricia |
| author_facet | Lee, S. Varano, J. Flexman, J. Cheng, W. Watson, M. Rossi, E. Adams, L. Bulsara, M. Price, Patricia |
| author_sort | Lee, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNa) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and inflammation at the start of treatment. Levels of soluble (s)CD30, interleukin-13 receptor alpha 2 (IL-13Ra2), total and active transforming growth factor-beta 1 (TGFß1), interleukin-18 (IL-18) and interferon-gamma inducible protein-10 (IP-10, CXCL10) were correlated with the severity of fibrosis and with treatment outcome using multiple logistic regression modelling. The Hepascore algorithm was confirmed as a marker of fibrosis, but was a poor predictor of treatment outcome. Inclusion of all immunological markers improved prediction based on Hepascore alone (p=0.045), but optimal prediction was achieved with an algorithm ("TIPscore") based on TGFß1 (total), IP-10, age, sex and HCV genotype (p=0.003 relative to Hepascore). Whilst this was only marginally more effective than predictions based on HCV genotype age and sex (p=0.07), it associates high TGFß1 and low IP-10 levels with a failure of therapy. © 2010 - IOS Press and the authors. All rights reserved. |
| first_indexed | 2025-11-14T09:06:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-41097 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:06:01Z |
| publishDate | 2010 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-410972017-09-13T14:28:47Z Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus Lee, S. Varano, J. Flexman, J. Cheng, W. Watson, M. Rossi, E. Adams, L. Bulsara, M. Price, Patricia The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNa) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and inflammation at the start of treatment. Levels of soluble (s)CD30, interleukin-13 receptor alpha 2 (IL-13Ra2), total and active transforming growth factor-beta 1 (TGFß1), interleukin-18 (IL-18) and interferon-gamma inducible protein-10 (IP-10, CXCL10) were correlated with the severity of fibrosis and with treatment outcome using multiple logistic regression modelling. The Hepascore algorithm was confirmed as a marker of fibrosis, but was a poor predictor of treatment outcome. Inclusion of all immunological markers improved prediction based on Hepascore alone (p=0.045), but optimal prediction was achieved with an algorithm ("TIPscore") based on TGFß1 (total), IP-10, age, sex and HCV genotype (p=0.003 relative to Hepascore). Whilst this was only marginally more effective than predictions based on HCV genotype age and sex (p=0.07), it associates high TGFß1 and low IP-10 levels with a failure of therapy. © 2010 - IOS Press and the authors. All rights reserved. 2010 Journal Article http://hdl.handle.net/20.500.11937/41097 10.3233/DMA-2010-0699 Hindawi Publishing Corporation restricted |
| spellingShingle | Lee, S. Varano, J. Flexman, J. Cheng, W. Watson, M. Rossi, E. Adams, L. Bulsara, M. Price, Patricia Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus |
| title | Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus |
| title_full | Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus |
| title_fullStr | Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus |
| title_full_unstemmed | Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus |
| title_short | Decreased IP-10 and elevated TGFß1 levels are associated with viral clearance following therapy in patients with hepatitis C virus |
| title_sort | decreased ip-10 and elevated tgfß1 levels are associated with viral clearance following therapy in patients with hepatitis c virus |
| url | http://hdl.handle.net/20.500.11937/41097 |